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Common variation ne...
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Kowalec, KaarinaKarolinska Institutet,Univ British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada
(författare)
Common variation near IRF6 is associated with IFN-beta-induced liver injury in multiple sclerosis
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-07-16
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Springer Science and Business Media LLC,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-364491
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364491URI
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https://doi.org/10.1038/s41588-018-0168-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138848706URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-β (IFN-β). Up to 60% of IFN-β-exposed MS patients develop abnormal biochemical liver test results1,2, and 1 in 50 experiences drug-induced liver injury3. Since genomic variation contributes to other forms of drug-induced liver injury4,5, we aimed to identify biomarkers of IFN-β-induced liver injury using a two-stage genome-wide association study. The rs2205986 variant, previously linked to differential expression of IRF6, surpassed genome-wide significance in the combined two-stage analysis (P = 2.3 × 10–8, odds ratio = 8.3, 95% confidence interval = 3.6–19.2). Analysis of an independent cohort of IFN-β-treated MS patients identified via electronic medical records showed that rs2205986 was also associated with increased peak levels of aspartate aminotransferase (P = 7.6 × 10–5) and alkaline phosphatase (P = 4.9 × 10-4). We show that these findings may be applicable to predicting IFN-β-induced liver injury, offering insight into its safer use.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wright, Galen E. B.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Dept Med Genet, Fac Med, Vancouver, BC, Canada
(författare)
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Drogemoller, Britt I.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
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Aminkeng, FolefacNatl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore;Agcy Sci Res & Technol, Translat Lab Genet Med, Singapore, Singapore
(författare)
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Bhavsar, Amit P.British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada;Univ Alberta, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB, Canada
(författare)
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Kingwell, ElaineUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
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Yoshida, Eric M.Univ British Columbia, Div Gastroenterol, Fac Med, Vancouver, BC, Canada
(författare)
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Traboulsee, AnthonyUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
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Marrie, Ruth AnnUniv Manitoba, Rady Fac Hlth Sci, Max Rady Coll Med, Dept Internal Med, Winnipeg, MB, Canada;Univ Manitoba, Rady Fac Hlth Sci, Max Rady Coll Med, Dept Community Hlth Sci, Winnipeg, MB, Canada
(författare)
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Kremenchutzky, MarceloWestern Univ, Fac Med, London Hlth Sci Ctr, London, ON, Canada;Western Univ, Fac Med, Dept Clin Neurol Sci, London, ON, Canada
(författare)
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Campbell, Trudy L.Dalhousie Univ, Dalhousie Multiple Sclerosis Res Uni, Halifax, NS, Canada;Dalhousie Univ, Sch Nursing, Halifax, NS, Canada
(författare)
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Duquette, PierreUniv Montreal, Dept Neurosci, Montreal, PQ, Canada
(författare)
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Chalasani, NagaIndiana Univ Sch Med, Div Gastroenterol Hepatol, Indianapolis, IN 46202 USA
(författare)
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Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)miawadel
(författare)
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Hallberg, Pär,1974-Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)pahal677
(författare)
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Xia, ZongqiUniv Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA
(författare)
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De Jager, Philip L.Columbia Univ, Med Ctr, Dept Neurol, Ctr Translat & Computat Neuroimmunol, New York, NY USA.;Columbia Univ, Med Ctr, Dept Neurol, Multiple Sclerosis Ctr, New York, NY USA.;Broad Inst, Cambridge, MA USA
(författare)
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Denny, Joshua C.Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.;Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA,British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada.;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
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Davis, Mary F.Brigham Young Univ, Dept Microbiol & Mol Biol, Provo, UT 84602 USA
(författare)
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Ross, Colin J. D.British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada.;Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
(författare)
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Tremlett, HelenUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada
(författare)
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Carleton, Bruce C.Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada.;British Columbia Childrens Hosp Res Inst, Vancouver, BC, Canada
(författare)
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Karolinska InstitutetUniv British Columbia, Div Neurol, Fac Med, Vancouver, BC, Canada;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Genetics: Springer Science and Business Media LLC50:8, s. 1081-+1061-40361546-1718
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- Av författaren/redakt...
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Kowalec, Kaarina
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Wright, Galen E. ...
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Drogemoller, Bri ...
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Aminkeng, Folefa ...
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Bhavsar, Amit P.
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Kingwell, Elaine
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visa fler...
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Yoshida, Eric M.
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Traboulsee, Anth ...
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Marrie, Ruth Ann
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Kremenchutzky, M ...
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Campbell, Trudy ...
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Duquette, Pierre
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Chalasani, Naga
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Wadelius, Mia
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Hallberg, Pär, 1 ...
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Xia, Zongqi
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De Jager, Philip ...
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Denny, Joshua C.
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Davis, Mary F.
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Ross, Colin J. D ...
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Tremlett, Helen
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Carleton, Bruce ...
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