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Recent advances in ...
Recent advances in the genomic and molecular biology of Giardia
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- Guadalupe Ortega-Pierres, M. (författare)
- IPN, Ctr Invest & Estudios Avanzados, Dept Genet & Mol Biol, Mexico City, DF, Mexico.
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- Jex, Aaron R. (författare)
- Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
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- Ansell, Brendan R. E. (författare)
- Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia.
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- Svärd, Staffan (författare)
- Uppsala universitet,Mikrobiologi
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IPN, Ctr Invest & Estudios Avanzados, Dept Genet & Mol Biol, Mexico City, DF, Mexico Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia.;Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia. (creator_code:org_t)
- ELSEVIER SCIENCE BV, 2018
- 2018
- Engelska.
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Ingår i: Acta Tropica. - : ELSEVIER SCIENCE BV. - 0001-706X .- 1873-6254. ; 184, s. 67-72
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Giardia duodenalis is the most common gastrointestinal protozoan parasite of humans and a significant contributor to the global burden of both diarrheal disease and post-infectious chronic disorders. Robust tools for analyzing gene function in this parasite have been developed and a range of genetic tools are now available. These together with public databases have provided insights on the function of different genes in Giardia. In this review we provide a current perspective on different molecular aspects of Giardia related to genomics, regulation of encystation, trophozoite transcriptional responses to physiological and xenobiotic (drug-induced) stress, and mechanisms of drug resistance. We also examine recent insights that have contributed to gain knowledge in the study of VSPs, antigenic variation, epigenetics, DNA repair and in the direct manipulation of gene function in Giardia, with a particular focus on the inducible Cre/loxP system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Giardia duodenalis
- Genomics
- Regulation of encystation
- Transcriptional responses
- Antigenic variation
- DNA repair
- Gene manipulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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