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PD-L1 Immunohistoch...
PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples : Results of Blueprint Phase 2 Project
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- Tsao, Ming Sound (författare)
- Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Dept Pathol, Toronto, ON, Canada
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- Kerr, Keith M. (författare)
- Aberdeen Univ Med Sch, Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland
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- Kockx, Mark (författare)
- HistoGeneX, Antwerp, Belgium
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- Beasley, Mary-Beth (författare)
- Mt Sinai Med Ctr, Dept Pathol, New York, NY 10029 USA
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- Borczuk, Alain C. (författare)
- Weill Cornell Med, Dept Pathol, New York, NY USA
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- Botling, Johan (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Bubendorf, Lukas (författare)
- Univ Hosp Basel, Pathol, Inst Pathol, Basel, Switzerland
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- Chirieac, Lucian (författare)
- Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA
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- Chen, Gang i (författare)
- Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200433, Peoples R China
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- Chou, Teh-Ying (författare)
- Taipei Vet Gen Hosp, Dept Pathol & Lab Med, Div Mol Pathol, Taipei, Taiwan
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- Chung, Jin-Haeng (författare)
- Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seongnam City, Gyeonggi Do, South Korea;Seoul Natl Univ, Bundang Hosp, Resp Ctr, Seongnam City, Gyeonggi Do, South Korea
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- Dacic, Sanja (författare)
- Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA
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- Lantuejoul, Sylvie (författare)
- Ctr Leon Berard, Dept Biopathol, Lyon, France
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- Mino-Kenudson, Mari (författare)
- Harvard Med Sch, Boston, MA USA;Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
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- Moreira, Andre L. (författare)
- NYU Langone Hlth, Dept Pathol, New York, NY USA
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- Nicholson, Andrew G. (författare)
- Royal Brompton & Harefield Natl Hlth Serv Fdn Tru, Dept Histopathol, London, England;Imperial Coll, Natl Heart & Lung Inst, London, England
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- Noguchi, Masayuki (författare)
- Univ Tsukuba, Fac Med, Dept Pathol, Tsukuba, Ibaraki, Japan
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- Pelosi, Giuseppe (författare)
- Univ Milan, Dept Oncol & Hematooncol, Milan, Italy;MultiMedica, IRCCS Grp, Milan, Italy
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- Poleri, Claudia s (författare)
- Off Pathol Consultants, Buenos Aires, DF, Argentina
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- Russell, Prudence A. (författare)
- St Vincents Pathol, Fitzroy, Vic, Australia
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- Sauter, Jennifer (författare)
- Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY USA
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- Thunnissen, Erik (författare)
- Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands
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- Wistuba, Ignacio (författare)
- MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX USA
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- Yu, Hui (författare)
- Univ Colorado, Anschutz Med Campus, Aurora, CO USA
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- Wynes, Murry W. (författare)
- Int Assoc Study Lung Canc, Aurora, CO USA
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- Pintilie, Melania (författare)
- Univ Hlth Network, Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON, Canada
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- Yatabe, Yasushi (författare)
- Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Nagoya, Aichi, Japan
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- Hirsch, Fred R. (författare)
- Univ Colorado, Anschutz Med Campus, Aurora, CO USA;Int Assoc Study Lung Canc, Aurora, CO USA
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Journal of Thoracic Oncology. - : Elsevier BV. - 1556-0864 .- 1556-1380. ; 13:9, s. 1302-1311
- Relaterad länk:
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http://www.jto.org/a...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: The Blueprint (BP) Programmed Death Ligand 1 (PD-L1) Immunohistochemistry Comparability Project is a pivotal academic/professional society and industrial collaboration to assess the feasibility of harmonizing the clinical use of five independently developed commercial PD-L1 immunohistochemistry assays. The goal of BP phase 2 (BP2) was to validate the results obtained in BP phase 1 by using real-world clinical lung cancer samples.Methods: BP2 were conducted using 81 lung cancer specimens of various histological and sample types, stained with all five trial-validated PD-L1 assays (22C3, 28-8, SP142, SP263, and 73-10); the slides were evaluated by an international panel of pathologists. BP2 also assessed the reliability of PD-L1 scoring by using digital images, and samples prepared for cytological examination. PD-L1 expression was assessed for percentage (tumor proportional score) of tumor cell (TC) and immune cell areas showing PD-L1 staining, with TCs scored continuously or categorically with the cutoffs used in checkpoint inhibitor trials.Results: The BP2 results showed highly comparable staining by the 22C3, 28-8 and SP263 assays; less sensitivity with the SP142 assay; and higher sensitivity with the 73-10 assay to detect PD-L1 expression on TCs. Glass slide and digital image scorings were highly concordant (Pearson correlation >0.96). There was very strong reliability among pathologists in TC PD-L1 scoring with all assays (overall intraclass correlation coefficient [ICC] = 0.86–0.93), poor reliability in IC PD-L1 scoring (overall ICC = 0.18–0.19), and good agreement in assessing PD-L1 status on cytological cell block materials (ICC = 0.78–0.85).Conclusion: BP2 consolidates the analytical evidence for interchangeability of the 22C3, 28-8, and SP263 assays and lower sensitivity of the SP142 assay for determining tumor proportion score on TCs and demonstrates greater sensitivity of the 73-10 assay compared with that of the other assays.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Immunooncology
- Checkpoint inhibitors
- Companion diagnostics
- Complementary diagnostics
- Cytology
- Pathology
- Patologi
- Pathology
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Till lärosätets databas
- Av författaren/redakt...
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Tsao, Ming Sound
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Kerr, Keith M.
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Kockx, Mark
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Beasley, Mary-Be ...
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Borczuk, Alain C ...
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Botling, Johan
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visa fler...
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Bubendorf, Lukas
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Chirieac, Lucian
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Chen, Gang i
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Chou, Teh-Ying
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Chung, Jin-Haeng
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Dacic, Sanja
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Lantuejoul, Sylv ...
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Mino-Kenudson, M ...
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Moreira, Andre L ...
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Nicholson, Andre ...
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Noguchi, Masayuk ...
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Pelosi, Giuseppe
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Poleri, Claudia ...
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Russell, Prudenc ...
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Sauter, Jennifer
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Thunnissen, Erik
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Wistuba, Ignacio
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Yu, Hui
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Wynes, Murry W.
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Pintilie, Melani ...
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Yatabe, Yasushi
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Hirsch, Fred R.
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