The Free Hormone Hypothesis: Is Free Serum 25-Hydroxyvitamin D a Better Marker for Bone Mineral Density in Older Women?

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Michaëlsson, Karl,1959-Uppsala universitet,Institutionen för kirurgiska vetenskaper (författare)

The Free Hormone Hypothesis : Is Free Serum 25-Hydroxyvitamin D a Better Marker for Bone Mineral Density in Older Women?

Artikel/kapitelEngelska2018

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2018-06-12
Wiley,2018
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-367518
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367518URI
https://doi.org/10.1002/jbm4.10059DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:230460340URI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

It is presently unclear whether free serum 25-hydroxyvitamin D (S-25(OH)D) better reflects bone health than total S-25(OH)D. We have previously shown that summer total S-25(OH)D values are more useful to predict bone mineral density (BMD) than winter values. Our objective was therefore to compare the relative importance of free and total S-25(OH)D for BMD by season. BMD was measured by dual-energy X-ray absorptiometry (DXA) in 5002 Swedish women (mean age 68 years) randomly selected from a large population-based longitudinal cohort study. Free S-25(OH)D was analyzed by a commercial ELISA and total S-25(OH)D by HPLC-tandem mass spectrometry (MS/MS). Free and total S-25(OH)D co-varied with season, with 26% and 29% higher values in August compared with those in January-March (nadir). There were no differences in mean BMD between categories of free or total S-25(OH)D in samples collected during winter. Women with higher total S-25(OH)D measured during summer had higher BMD at the total hip. Compared with women who had total S-25(OH)D values above 80 nmol/L during summer, adjusted BMD at the total hip was 6% (95% CI, 1% to 11%) lower for S-25(OH)D concentrations between 30 and 40 mmol/L, and 11% (95% CI, 3% to 19%) lower for those with total S-25(OH)D <30 nmol/L. In contrast, free S-25(OH)D measured during summer was not associated with BMD. Compared with women who had highest free S-25(OH)D measured during summer (>8.8 pmol/L), those with intermediate (2.4-3.5 pmol/L) and lowest (<2.4 pmol/L) free S-25(OH)D during summer did not have lower total hip BMD values (3% [95% CI, -2% to 7%] and -2% [95% CI, -8% to 4%]). In addition, we found no added value for the prediction of BMD with the combined measurement of total and free S-25(OH)D during summer or winter. We conclude that vitamin D status assessed by direct measurements of free S-25(OH)D does not reflect BMD better than total S-25(OH)D. © 2018 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
DXA
EPIDEMIOLOGY
OSTEOPOROSIS
STATISTICAL METHODS
VITAMIN D

Biuppslag (personer, institutioner, konferenser, titlar ...)

Jacobson, AnnicaUppsala universitet,Klinisk farmakogenomik och osteoporos(Swepub:uu)annijaco (författare)
Wolk, AlicjaKarolinska Institutet(Swepub:uu)alwol516 (författare)
Byberg, LiisaUppsala universitet,Ortopedi,Medicinsk epidemiologi(Swepub:uu)liisbybe (författare)
Mitchell, Adam (författare)
Melhus, HåkanUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)hakamelh (författare)
Rasmusson, A (författare)
Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:JBMR plus: Wiley2:6, s. 367-3742473-4039

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Av författaren/redakt...: Michaëlsson, Kar ...; Jacobson, Annica; Wolk, Alicja; Byberg, Liisa; Mitchell, Adam; Melhus, Håkan; visa fler...; Rasmusson, A; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Ortopedi

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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