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Serum 25-Hydroxyvit...
Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.
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- Larsson, Susanna C (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi
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Traylor, Matthew (författare)
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Mishra, Aniket (författare)
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Howson, Joanna M M (författare)
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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Markus, Hugh S (författare)
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 49:10, s. 2508-2511
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and Purpose- Observational studies have reported increased risk of ischemic stroke among individuals with low serum 25-hydroxyvitamin D (S-25OHD) concentrations but uncertainty remains about the causality of this association. We sought to determine whether S-25OHD concentrations are causally associated with ischemic stroke and its subtypes using Mendelian randomization. Methods- We used summary-level data for ischemic stroke (34 217 cases and 404 630 noncases) from the MEGASTROKE consortium. As instruments, we used 6 single nucleotide polymorphisms, explaining 7.5% of the variance in S-25OHD, previously identified to be associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits consortium (n=79 366). The analyses were conducted using the inverse-variance-weighted method and complemented with the weighted median, heterogeneity-penalized, and Mendelian randomization-Egger approaches. Results- Genetically higher S-25OHD concentration was not associated with ischemic stroke. The odds ratios (95% CI) per genetically predicted 1-SD (≈18 nmol/L) increase in S-25OHD concentrations, based on all 6 single nucleotide polymorphisms, were 1.01 (0.94-1.08; P=0.84) for all ischemic stroke, 0.94 (0.80-1.11; P=0.49) for large artery stroke, 0.95 (0.82-1.11; P=0.55) for small vessel stroke, and 1.02 (0.90-1.16; P=0.74) for cardioembolic stroke. The results were similar in sensitivity analyses. Conclusions- These findings provide no support that higher S-25OHD concentrations are causally associated with any ischemic stroke subtype. Thus, vitamin D supplementation will unlikely reduce the risk of ischemic stroke in the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- 25-hydroxyvitamin D
- polymorphisms
- single nucleotide
- random allocation
- stroke
- vitamin D
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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