Sökning: onr:"swepub:oai:DiVA.org:uu-368147" > Circulating Metabol...
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000 | 07078naa a2201249 4500 | |
001 | oai:DiVA.org:uu-368147 | |
003 | SwePub | |
008 | 181204s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140739136 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681472 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-18-00792 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1407391362 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Adams, Charleenu MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; University of Bristol, Bristol, United Kingdom.4 aut |
245 | 1 0 | a Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study |
264 | 1 | b American Association for Cancer Research (AACR),c 2019 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).MATERIALS AND METHODS: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PSA) screening for prostate cancer within the Prostate testing for cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium.RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (p <0.0014, multiple-testing threshold). These fell into four classes: i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); ii) fatty acids and ratios; iii) amino acids; iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal.CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
700 | 1 | a Richmond, Rebecca C.4 aut |
700 | 1 | a Santos Ferreira, Diana L4 aut |
700 | 1 | a Spiller, Wes4 aut |
700 | 1 | a Tan, Vanessa Y4 aut |
700 | 1 | a Zheng, Jie4 aut |
700 | 1 | a Wurtz, Peter4 aut |
700 | 1 | a Donovan, Jenny L4 aut |
700 | 1 | a Hamdy, Freddie C4 aut |
700 | 1 | a Neal, David E4 aut |
700 | 1 | a Lane, J Athene4 aut |
700 | 1 | a Davey Smith, George4 aut |
700 | 1 | a Relton, Caroline L4 aut |
700 | 1 | a Eeles, Rosalind A4 aut |
700 | 1 | a Henderson, Brian E4 aut |
700 | 1 | a Haiman, Christopher A4 aut |
700 | 1 | a Kote-Jarai, Zsofia4 aut |
700 | 1 | a Schumacher, Fredrick R4 aut |
700 | 1 | a Amin Al Olama, Ali4 aut |
700 | 1 | a Benlloch, Sara4 aut |
700 | 1 | a Muir, Kenneth4 aut |
700 | 1 | a Berndt, Sonja I4 aut |
700 | 1 | a Conti, David V4 aut |
700 | 1 | a Wiklund, Fredriku Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Gapstur, Susan M4 aut |
700 | 1 | a Stevens, Victoria L4 aut |
700 | 1 | a Tangen, Catherine M4 aut |
700 | 1 | a Batra, Jyotsna4 aut |
700 | 1 | a Clements, Judith A4 aut |
700 | 1 | a Grönberg, Henriku Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.4 aut |
700 | 1 | a Pashayan, Nora4 aut |
700 | 1 | a Schleutker, Johanna4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet,Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.4 aut0 (Swepub:uu)alwol516 |
700 | 1 | a West, Catharine M L4 aut |
700 | 1 | a Mucci, Lorelei A4 aut |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Koutros, Stella4 aut |
700 | 1 | a Sørensen, Karina D4 aut |
700 | 1 | a Maehle, Lovise4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Hamilton, Robert4 aut |
700 | 1 | a Ingles, Sue Ann4 aut |
700 | 1 | a Rosenstein, Barry S4 aut |
700 | 1 | a Lu, Yong-Jie4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Kibel, Adam S4 aut |
700 | 1 | a Vega, Ana4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Penney, Kathryn L4 aut |
700 | 1 | a Park, Jong Y4 aut |
700 | 1 | a Stanford, Janet L4 aut |
700 | 1 | a Cybulski, Cezary4 aut |
700 | 1 | a Nordestgaard, Borge G4 aut |
700 | 1 | a Brenner, Hermann4 aut |
700 | 1 | a Maier, Christiane4 aut |
700 | 1 | a Kim, Jeri4 aut |
700 | 1 | a John, Esther M4 aut |
700 | 1 | a Teixeira, Manuel R4 aut |
700 | 1 | a Neuhausen, Susan L4 aut |
700 | 1 | a DeRuyck, Kim4 aut |
700 | 1 | a Razack, Azad4 aut |
700 | 1 | a Newcomb, Lisa F4 aut |
700 | 1 | a Lessel, Davor4 aut |
700 | 1 | a Kaneva, Radka P4 aut |
700 | 1 | a Usmani, Nawaid4 aut |
700 | 1 | a Claessens, Frank4 aut |
700 | 1 | a Townsend, Paul4 aut |
700 | 1 | a Gago Dominguez, Manuela4 aut |
700 | 1 | a Roobol, Monique J4 aut |
700 | 1 | a Menegaux, Florence4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Cannon-Albright, Lisa A4 aut |
700 | 1 | a Pandha, Hardev4 aut |
700 | 1 | a Thibodeau, Stephen N4 aut |
700 | 1 | a Martin, Richard M4 aut |
710 | 2 | a Karolinska Institutetb MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; University of Bristol, Bristol, United Kingdom.4 org |
773 | 0 | t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 28:1, s. 208-216q 28:1<208-216x 1055-9965x 1538-7755 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368147 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-18-0079 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140739136 |
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