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Proteomic diversity...
Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species
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- Emery-Corbin, Samantha J. (författare)
- Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia
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- Vuong, Daniel (författare)
- Microbial Screening Technol, Smithfield, NSW, Australia
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- Lacey, Ernest (författare)
- Microbial Screening Technol, Smithfield, NSW, Australia;Macquarie Univ, Fac Sci, Chem & Biomol Sci, N Ryde, NSW, Australia
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- Svärd, Staffan (författare)
- Uppsala universitet,Mikrobiologi
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- Ansell, Brendan R. E. (författare)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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- Jex, Aaron R. (författare)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi,Univ Melbourne, Fac Vet & Agr Sci, Melbourne, Vic, Australia
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2018
- 2018
- Engelska.
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Ingår i: International Journal of Parasitology. - : ELSEVIER SCI LTD. - 0020-7519 .- 1879-0135. ; 48:11, s. 817-823
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Giardia duodenalis a species complex of gastrointestinal protists, with assemblages A and B infective to humans. To date, post-genomic proteomics are largely derived from Assemblage A, biasing understanding of parasite biology. To address this gap, we quantitatively analysed the proteomes of trophozoites from the genome reference and two clinical Assemblage B isolates, revealing lower spectrum-to-peptide matches in non-reference isolates, resulting in significant losses in peptide and protein identifications, and indicating significant intra-assemblage variation. We also explored differential protein expression between in vitro cultured subpopulations putatively enriched for dividing and feeding cells, respectively. This data is an important proteomic baseline for Assemblage B, highlighting proteomic differences between physiological states, and unique differences relative to Assemblage A.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Giardia duodenalis
- Assemblage B
- Label-free proteomics
- Protozoology
- Comparative proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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