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Proteomic approach ...
Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib
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- Karademir, Betul (författare)
- Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey
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- Sari, Gulce (författare)
- Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey;Okan Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey
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- Jannuzzi, Ayse Tarbin (författare)
- Istanbul Univ, Fac Pharm, Dept Pharmaceut Toxicol, Istanbul, Turkey
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- Musunuri, Sravani (författare)
- Uppsala universitet,Analytisk kemi
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- Wicher, Grzegorz (författare)
- Uppsala universitet,Neuroonkologi
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- Grune, Tilman (författare)
- German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany
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- Mi, Jia (författare)
- Uppsala universitet,Analytisk kemi,Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China
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- Hacioglu-Bay, Husniye (författare)
- Marmara Univ, Sch Med, Dept Anat, Istanbul, Turkey
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- Forsberg-Nilsson, Karin, 1963- (författare)
- Uppsala universitet,Neuroonkologi
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
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- Jung, Tobias (författare)
- German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany
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(creator_code:org_t)
- 2018-11-05
- 2018
- Engelska.
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical applications. However neuropathic side effects are dose limiting for BTZ as many other chemotherapeutic agents. Therefore second-generation proteasome inhibitors have been developed including carfilzomib (CFZ). Aim of the present work was investigating the mechanisms of peripheral neuropathy triggered by the proteasome inhibitor BTZ and comparing the pathways affected by BTZ and CFZ, respectively. Neural stem cells, isolated from the cortex of E14 mouse embryos, were treated with BTZ and CFZ and mass spectrometry was used to compare the global protein pool of treated cells. BTZ was shown to cause more severe cytoskeletal damage, which is crucial in neural cell integrity. Excessive protein carbonylation and actin filament destabilization were also detected following BTZ treatment that was lower following CFZ treatment. Our data on cytoskeletal proteins, chaperone system, and protein oxidation may explain the milder neurotoxic effects of CFZ in clinical applications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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Karademir, Betul
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Sari, Gulce
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Jannuzzi, Ayse T ...
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Musunuri, Sravan ...
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Wicher, Grzegorz
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Grune, Tilman
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Mi, Jia
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Hacioglu-Bay, Hu ...
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Forsberg-Nilsson ...
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Bergquist, Jonas
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Jung, Tobias
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- MEDICIN OCH HÄLSOVETENSKAP
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och Cell och molekyl ...
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Uppsala universitet