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Arterial Spin-Label...
Arterial Spin-Labeling in Children with Brain Tumor : A Meta-Analysis
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- Delgado, A. F. (författare)
- Uppsala University,Karolinska Institutet
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- De Luca, F. (författare)
- Univ G DAnnunzio, Sch Med & Hlth Sci, Fac Med & Surg, Chieti, Italy,University G.d'Annunzio of Chieti-Pescara
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- Hanagandi, P. (författare)
- Karolinska Institutet
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- Van Westen, D. (författare)
- Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups
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- Falk Delgado, Alberto (författare)
- Uppsala universitet,Plastikkirurgi
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(creator_code:org_t)
- AMER SOC NEURORADIOLOGY, 2018
- 2018
- Engelska.
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Ingår i: American Journal of Neuroradiology. - : AMER SOC NEURORADIOLOGY. - 0195-6108 .- 1936-959X. ; 39:8, s. 1536-1542
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
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- BACKGROUND:The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE:Our aim was to assess the diagnostic accuracy of arterial spin-labeling-derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES:MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION:Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS:Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS:Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43-48.82 mL/min/100 g), I-2 = 74, P = .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P < .001, I-2 = 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve = 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method. LIMITATIONS:Included tumor types, analysis method, and original data varied among included studies. CONCLUSIONS:Arterial spin-labeling-derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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