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Multiple roles of l...
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Bovay, EstherCHU Vaudois, Dept Oncol, Epalinges, Switzerland;Univ Lausanne, Epalinges, Switzerland
(författare)
Multiple roles of lymphatic vessels in peripheral lymph node development
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-10-24
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Rockefeller University Press,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-369591
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369591URI
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https://doi.org/10.1084/jem.20180217DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139537732URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying development of this highly organized system are not fully understood. Using highresolution imaging, we show that lymphoid tissue inducer (LTi) cells initially transmigrate from veins at LN development sites using gaps in venous mural coverage. This process is independent of lymphatic vasculature, but lymphatic vessels are indispensable for the transport of LTi cells that egress from blood capillaries elsewhere and serve as an essential LN expansion reservoir. At later stages, lymphatic collecting vessels ensure efficient LTi cell transport and formation of the LN capsule and subcapsular sinus. Perinodal lymphatics also promote local interstitial flow, which cooperates with lymphotoxin-beta signaling to amplify stromal CXCL13 production and thereby promote LTi cell retention. Our data unify previous models of LN development by showing that lymphatics intervene at multiple points to assist LN expansion and identify a new role for mechanical forces in LN development.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sabine, AmelieCHU Vaudois, Dept Oncol, Epalinges, Switzerland;Univ Lausanne, Epalinges, Switzerland
(författare)
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Prat-Luri, BorjaCHU Vaudois, Dept Oncol, Epalinges, Switzerland;Univ Lausanne, Epalinges, Switzerland
(författare)
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Kim, SudongSeoul Natl Univ, Sch Mech & Aerosp Engn, Seoul, South Korea
(författare)
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Son, KyungminSeoul Natl Univ, Sch Mech & Aerosp Engn, Seoul, South Korea
(författare)
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Willrodt, Ann-HelenSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland
(författare)
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Olsson, CeciliaUppsala universitet,Institutionen för immunologi, genetik och patologi
(författare)
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Halin, CorneliaSwiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland
(författare)
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Kiefer, FriedemannMax Planck Inst Mol Biomed, Munster, Germany;Univ Munster, European Inst Mol Imaging, Munster, Germany
(författare)
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Betsholtz, ChristerKarolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, Dept Med Huddinge, Stockholm, Sweden(Swepub:uu)chbet517
(författare)
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Li Jeon, NooSeoul Natl Univ, Sch Mech & Aerosp Engn, Seoul, South Korea
(författare)
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Luther, Sanjiv A.Univ Lausanne, Dept Biochem, Epalinges, Switzerland
(författare)
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Petrova, Tatiana, VCHU Vaudois, Dept Oncol, Epalinges, Switzerland;Univ Lausanne, Epalinges, Switzerland;Ludwig Inst Canc Res, Epalinges, Switzerland;Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, Lausanne, Switzerland;CHU Vaudois, Div Expt Pathol, Lausanne, Switzerland
(författare)
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CHU Vaudois, Dept Oncol, Epalinges, Switzerland;Univ Lausanne, Epalinges, SwitzerlandSeoul Natl Univ, Sch Mech & Aerosp Engn, Seoul, South Korea
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Experimental Medicine: Rockefeller University Press215:11, s. 2760-27770022-10071540-9538
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Bovay, Esther
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Sabine, Amelie
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Prat-Luri, Borja
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Kim, Sudong
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Son, Kyungmin
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Willrodt, Ann-He ...
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visa fler...
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Olsson, Cecilia
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Halin, Cornelia
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Kiefer, Friedema ...
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Betsholtz, Chris ...
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Li Jeon, Noo
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Luther, Sanjiv A ...
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Petrova, Tatiana ...
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Uppsala universitet
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