Sökning: onr:"swepub:oai:DiVA.org:uu-372078" > Trans-ethnic kidney...
Fältnamn | Indikatorer | Metadata |
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000 | 06753naa a2201297 4500 | |
001 | oai:DiVA.org:uu-372078 | |
003 | SwePub | |
008 | 190104s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:du-29255 | |
009 | oai:prod.swepub.kib.ki.se:139952955 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3720782 URI |
024 | 7 | a https://doi.org/10.1038/s41467-018-07867-72 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-292552 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1399529552 URI |
040 | a (SwePub)uud (SwePub)dud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Morris, Andrew P4 aut |
245 | 1 0 | a Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies |
264 | c 2019-01-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. Fine-mapping reveals 40 high-confidence variants driving eGFR associations and highlights putative causal genes with cell-type specific expression in glomerulus, and in proximal and distal nephron. Mendelian randomisation supports causal effects of eGFR on overall and cause-specific CKD, kidney stone formation, diastolic blood pressure and hypertension. These results define novel molecular mechanisms and putative causal genes for eGFR, offering insight into clinical outcomes and routes to CKD treatment development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a Hälsa och välfärd | |
700 | 1 | a Le, Thu H4 aut |
700 | 1 | a Wu, Haojia4 aut |
700 | 1 | a Akbarov, Artur4 aut |
700 | 1 | a van der Most, Peter J4 aut |
700 | 1 | a Hemani, Gibran4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Gaulton, Kyle J4 aut |
700 | 1 | a Nadkarni, Girish N4 aut |
700 | 1 | a Valladares-Salgado, Adan4 aut |
700 | 1 | a Wacher-Rodarte, Niels4 aut |
700 | 1 | a Mychaleckyj, Josyf C4 aut |
700 | 1 | a Dueker, Nicole D4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Hai, Yang4 aut |
700 | 1 | a Haessler, Jeffrey4 aut |
700 | 1 | a Kamatani, Yoichiro4 aut |
700 | 1 | a Stilp, Adrienne M4 aut |
700 | 1 | a Zhu, Gu4 aut |
700 | 1 | a Cook, James P4 aut |
700 | 1 | a Ärnlöv, Johanu Karolinska Institutet,Högskolan Dalarna,Uppsala universitet,Centrum för klinisk forskning Dalarna,Medicinsk vetenskap4 aut0 (Swepub:du)jan |
700 | 1 | a Blanton, Susan H4 aut |
700 | 1 | a de Borst, Martin H4 aut |
700 | 1 | a Bottinger, Erwin P4 aut |
700 | 1 | a Buchanan, Thomas A4 aut |
700 | 1 | a Cechova, Sylvia4 aut |
700 | 1 | a Charchar, Fadi J4 aut |
700 | 1 | a Chu, Pei-Lun4 aut |
700 | 1 | a Damman, Jeffrey4 aut |
700 | 1 | a Eales, James4 aut |
700 | 1 | a Gharavi, Ali G4 aut |
700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
700 | 1 | a Heath, Andrew C4 aut |
700 | 1 | a Ipp, Eli4 aut |
700 | 1 | a Kiryluk, Krzysztof4 aut |
700 | 1 | a Kramer, Holly J4 aut |
700 | 1 | a Kubo, Michiaki4 aut |
700 | 1 | a Larsson, Andersu Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)andlarss |
700 | 1 | a Lindgren, Cecilia M4 aut |
700 | 1 | a Lu, Yingchang4 aut |
700 | 1 | a Madden, Pamela A F4 aut |
700 | 1 | a Montgomery, Grant W4 aut |
700 | 1 | a Papanicolaou, George J4 aut |
700 | 1 | a Raffel, Leslie J4 aut |
700 | 1 | a Sacco, Ralph L4 aut |
700 | 1 | a Sanchez, Elena4 aut |
700 | 1 | a Stark, Holger4 aut |
700 | 1 | a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Molekylär epidemiologi4 aut0 (Swepub:uu)johasund |
700 | 1 | a Taylor, Kent D4 aut |
700 | 1 | a Xiang, Anny H4 aut |
700 | 1 | a Zivkovic, Aleksandra4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, Stanford Univ, Stanford Cardiovasc Inst, Stanford, USA; Stanford Univ, Stanford Diabet Res Ctr, Stanford, USA4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Martin, Nicholas G4 aut |
700 | 1 | a Whitfield, John B4 aut |
700 | 1 | a Cai, Jianwen4 aut |
700 | 1 | a Laurie, Cathy C4 aut |
700 | 1 | a Okada, Yukinori4 aut |
700 | 1 | a Matsuda, Koichi4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Rundek, Tatjana4 aut |
700 | 1 | a Rich, Stephen S4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
700 | 1 | a Parra, Esteban J4 aut |
700 | 1 | a Cruz, Miguel4 aut |
700 | 1 | a Rotter, Jerome I4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Tomaszewski, Maciej4 aut |
700 | 1 | a Humphreys, Benjamin D4 aut |
700 | 1 | a Franceschini, Nora4 aut |
710 | 2 | a Uppsala universitetb Centrum för klinisk forskning Dalarna4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1275304/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41467-018-07867-7.pdf |
856 | 4 | u https://doi.org/10.1038/s41467-018-07867-7y Fulltext |
856 | 4 | u https://du.diva-portal.org/smash/get/diva2:1275697/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372078 |
856 | 4 8 | u https://doi.org/10.1038/s41467-018-07867-7 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-29255 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139952955 |
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