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Sökning: onr:"swepub:oai:DiVA.org:uu-375564" > Biochemical Differe...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03712naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-375564 | |
| 003 | SwePub | |
| 008 | 190131s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3755642 URI |
| 024 | 7 | a https://doi.org/10.3390/cells80200842 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Herman, Stephanieu Uppsala universitet,Klinisk kemi,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab,Spjuth group4 aut0 (Swepub:uu)stehe524 |
| 245 | 1 0 | a Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing-Remitting Multiple Sclerosis |
| 264 | c 2019-01-24 | |
| 264 | 1 | b MDPI AG,c 2019 |
| 338 | a electronic2 rdacarrier | |
| 520 | a To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify potential biomarkers of disease progression, we applied high-resolution mass spectrometry (HRMS) to investigate the metabolome of cerebrospinal fluid (CSF). The biochemical differences were determined using partial least squares discriminant analysis (PLS-DA) and connected to biochemical pathways as well as associated to clinical and radiological measures. Tryptophan metabolism was significantly altered, with perturbed levels of kynurenate, 5-hydroxytryptophan, 5-hydroxyindoleacetate, and N-acetylserotonin in SPMS patients compared with RRMS and controls. SPMS patients had altered kynurenine compared with RRMS patients, and altered indole-3-acetate compared with controls. Regarding the pyrimidine metabolism, SPMS patients had altered levels of uridine and deoxyuridine compared with RRMS and controls, and altered thymine and glutamine compared with RRMS patients. Metabolites from the pyrimidine metabolism were significantly associated with disability, disease activity and brain atrophy, making them of particular interest for understanding the disease mechanisms and as markers of disease progression. Overall, these findings are of importance for the characterization of the molecular pathogenesis of SPMS and support the hypothesis that the CSF metabolome may be used to explore changes that occur in the transition between the RRMS and SPMS pathologies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a cerebrospinal fluid | |
| 653 | a mass spectrometry | |
| 653 | a metabolomics | |
| 653 | a multiple sclerosis | |
| 653 | a pyrimidine | |
| 653 | a tryptophan | |
| 700 | 1 | a Åkerfeldt, Torbjörnu Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)tak20812 |
| 700 | 1 | a Spjuth, Ola,c Docent,d 1977-u Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)olspj499 |
| 700 | 1 | a Burman, Joachim,d 1974-u Uppsala universitet,Neurologi4 aut0 (Swepub:uu)joabu293 |
| 700 | 1 | a Kultima, Kimu Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)kikul535 |
| 710 | 2 | a Uppsala universitetb Klinisk kemi4 org |
| 773 | 0 | t Cellsd : MDPI AGg 8:2q 8:2x 2073-4409 |
| 856 | 4 | u https://doi.org/10.3390/cells8020084y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1284187/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.mdpi.com/2073-4409/8/2/84/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-375564 |
| 856 | 4 8 | u https://doi.org/10.3390/cells8020084 |
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