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Stroke Outcomes Wit...
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Ungar, LeoUniv Calif Irvine, Dept Cardiol, Med Ctr, Orange, CA 92668 USA
(författare)
Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes : Insights From the TRACER Trial
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-375901
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-375901URI
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https://doi.org/10.1161/JAHA.118.009609DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BackgroundVorapaxar, a protease‐activated receptor‐1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage.Methods and ResultsTRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) was a trial of vorapaxar versus placebo among patients with acute coronary syndrome. Strokes were adjudicated by a central events committee. Of 12 944 patients, 199 (1.5%) had ≥1 stroke during the study period (median follow‐up, 477 days). Four patients had a single stroke of unknown type; 195 patients had ≥1 stroke classified as hemorrhagic or nonhemorrhagic (165 nonhemorrhagic, 28 hemorrhagic, and 2 both). Strokes occurred in 96 of 6473 patients (1.5%) assigned vorapaxar and 103 of 6471 patients (1.6%) assigned placebo. Kaplan‐Meier incidence of stroke for vorapaxar versus placebo was higher for hemorrhagic stroke (0.45% versus 0.14% [hazard ratio, 2.74; 95% confidence interval, 1.22–6.15]), lower but not significantly different for nonhemorrhagic stroke (1.53% versus 1.98% at 2 years [hazard ratio, 0.79; 95% confidence interval, 0.58–1.07]), and similar for stroke overall (1.93% versus 2.13% at 2 years [hazard ratio, 0.94; 95% confidence interval, 0.71–1.24]).ConclusionsStroke occurred in <2% of patients. Vorapaxar‐assigned patients had increased hemorrhagic stroke but a nonsignificant trend toward lower nonhemorrhagic stroke. Overall stroke frequency was similar with vorapaxar versus placebo.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Clare, Robert M.Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA
(författare)
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Rodriguez, FatimaStanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA USA
(författare)
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Kolls, Bradley J.Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA
(författare)
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Armstrong, Paul W.Univ Alberta, Div Cardiol, Edmonton, AB, Canada
(författare)
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Aylward, PhilipFlinders Univ S Australia, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia;Med Ctr, Adelaide, SA, Australia
(författare)
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Held, Claes,1956-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)clahe947
(författare)
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Moliterno, David J.Univ Kentucky, Gill Heart Inst, Div Cardiovasc Med, Lexington, KY USA
(författare)
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Strony, JohnJohnson & Johnson, New Brunswick, NJ USA
(författare)
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Van de Werf, FransUniv Hosp Leuven, Dept Cardiovasc Sci, Leuven, Belgium
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(författare)
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White, Harvey D.Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand
(författare)
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Tricoci, PierluigiDuke Clin Res Inst, Dept Med, Durham, NC 27710 USA
(författare)
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Harrington, Robert A.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
(författare)
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Mahaffey, Kenneth W.Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
(författare)
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Melloni, ChiaraDuke Clin Res Inst, Dept Med, Durham, NC 27710 USA
(författare)
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Univ Calif Irvine, Dept Cardiol, Med Ctr, Orange, CA 92668 USADuke Clin Res Inst, Dept Med, Durham, NC 27710 USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the American Heart Association7:242047-9980
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Ungar, Leo
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Clare, Robert M.
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Rodriguez, Fatim ...
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Kolls, Bradley J ...
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Armstrong, Paul ...
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Aylward, Philip
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Held, Claes, 195 ...
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Moliterno, David ...
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Strony, John
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Van de Werf, Fra ...
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Wallentin, Lars, ...
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White, Harvey D.
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Tricoci, Pierlui ...
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Harrington, Robe ...
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Mahaffey, Kennet ...
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Melloni, Chiara
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