A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H

• The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid and its properties as a substrate for the RNase H, as well as to point the crucial structural requirements for the modified AONs to preserve their RNase H potency.

Nyckelord

structure; DNA/RNA hybrid; AONs; RNase H; COLI RIBONUCLEASE HI; ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; ARABINONUCLEIC ACIDS ANA; LOCKED NUCLEIC-ACID; ESCHERICHIA-COLI; DNA-REPLICATION; HYBRID DUPLEXES; MESSENGER-RNA; THERAPEUTIC AGENTS; COMPLEMENTARY RNA

Publikations- och innehållstyp

vet (ämneskategori)

rec (ämneskategori)