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Effects of oxidatio...
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Parra-Ortiz, ElisaUniv Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
(författare)
Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
- Artikel/kapitelEngelska2019
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ACADEMIC PRESS INC ELSEVIER SCIENCE,2019
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LIBRIS-ID:oai:DiVA.org:uu-378622
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-378622URI
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https://doi.org/10.1016/j.jcis.2018.12.007DOI
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Språk:engelska
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Sammanfattning på:engelska
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The exposure of biological membranes to reactive oxygen species (ROS) plays an important role in many pathological conditions such as inflammation, infection, or sepsis. ROS also modulate signaling processes and produce markers for damaged tissue. Lipid peroxidation, mainly affecting polyunsaturated phospholipids, results in a complex mixture of oxidized products, which may dramatically alter membrane properties. Here, we have employed a set of biophysical and surface-chemical techniques, including neutron and X-ray scattering, to study the structural, compositional, and stability changes due to oxidative stress on phospholipid bilayers composed of lipids with different degrees of polyunsaturation. In doing so, we obtained real-time information about bilayer degradation under in situ UV exposure using neutron reflectometry. We present a set of interrelated physicochemical effects, including gradual increases in area per molecule, head group and acyl chain hydration, as well as bilayer thinning, lateral phase separation, and defect formation leading to content loss upon membrane oxidation. Such effects were observed to depend on the presence of polyunsaturated phospholipids in the lipid membrane, suggesting that these may also play a role in the complex oxidation processes occurring in cells.
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Browning, Kathryn L.Univ Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
(författare)
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Damgaard, Liv S. E.Univ Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
(författare)
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Nordström, RandiUppsala universitet,Institutionen för farmaci(Swepub:uu)ranra372
(författare)
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Micciulla, SamanthaInst Laue Langevin, F-38000 Grenoble, France
(författare)
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Bucciarelli, SaskiaUniv Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark
(författare)
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Malmsten, MartinUppsala universitet,Institutionen för farmaci,Univ Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark(Swepub:uu)mamal991
(författare)
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Univ Copenhagen, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, DenmarkInstitutionen för farmaci
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Colloid and Interface Science: ACADEMIC PRESS INC ELSEVIER SCIENCE538, s. 404-4190021-97971095-7103
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