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Relapse Risk and Lo...
Relapse Risk and Loss of Lifetime After Modern Combined Modality Treatment of Young Patients With Hodgkin Lymphoma : A Nordic Lymphoma Epidemiology Group Study
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- Biccler, Jorne Lionel (författare)
- Aalborg Univ Hosp, Aalborg, Denmark;Aalborg Univ, Aalborg, Denmark,Aalborg University Hospital
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- Glimelius, Ingrid, 1975- (författare)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Solna, Sweden,Uppsala University Hospital
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- Eloranta, Sandra (författare)
- Karolinska Institute,Karolinska Institutet
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- Smeland, Knut B. (författare)
- Oslo Univ Hosp, Oslo, Norway,Oslo university hospital
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- Brown, Peter de Nully (författare)
- Copenhagen Univ Hosp, Copenhagen, Denmark,Copenhagen University Hospital
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- Jakobsen, Lasse Hjort (författare)
- Aalborg Univ Hosp, Aalborg, Denmark;Aalborg Univ, Aalborg, Denmark,Aalborg University Hospital
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- Frederiksen, Henrik (författare)
- Odense Univ Hosp, Odense, Denmark,Odense University Hospital
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- Jerkeman, Mats (författare)
- Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,Lymphoma - Clinical Research,Lund University Research Groups
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- Fosså, Alexander (författare)
- Oslo Univ Hosp, Oslo, Norway;KG Jebsen Ctr B Cell Malignancies, Oslo, Norway,University of Oslo,Oslo university hospital
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- Andersson, Therese M. L. (författare)
- Karolinska Institute,Karolinska Institutet
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- Holte, Harald (författare)
- Oslo Univ Hosp, Oslo, Norway;KG Jebsen Ctr B Cell Malignancies, Oslo, Norway,University of Oslo,Oslo university hospital
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- Bögsted, Martin (författare)
- Aalborg Univ Hosp, Aalborg, Denmark;Aalborg Univ, Aalborg, Denmark,Aalborg University Hospital
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- El-Galaly, Tarec Christoffer (författare)
- Aalborg Univ Hosp, Aalborg, Denmark;Aalborg Univ, Aalborg, Denmark,Aalborg University Hospital
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- Smedby, Karin E. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- AMER SOC CLINICAL ONCOLOGY, 2019
- 2019
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 37:9, s. 703-713
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- PURPOSE: Estimates of short- and long-term survival for young patients with classic Hodgkin lymphoma (cHL) are of considerable interest. We investigated cHL prognosis in the era of contemporary treatment at different milestones during the follow-up.PATIENTS AND METHODS: On the basis of a Nordic cohort of 2,582 patients diagnosed at ages 18 to 49 years between 2000 and 2013, 5-year relapse risks and 5-year restricted losses in expectation of lifetime were estimated for all patients and for patients who achieved event-free survival (EFS) for 12 (EFS12), 24 (EFS24), 36 (EFS36) or 60 (EFS60) months. The median follow-up time was 9 years (range, 2.9 to 16.8 years).RESULTS: The 5-year overall survival was 95% (95% CI, 94% to 96%). The 5-year risk of relapse was 13.4% (95% CI, 12.1% to 14.8%) overall but decreased to 4.2% (95% CI, 3.8% to 4.6%) given that patients reached EFS24. Relapse risk for patients treated with six to eight courses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) was comparable to that of patients treated with six to eight courses of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) despite more adverse risk criteria among patients treated with BEACOPP. Both from diagnosis and if EFS24 was reached, the losses in expectation of lifetime during the following 5 years were small (from diagnosis, 45 days [95% CI, 35 to 54 days] and for patients who reached EFS24, 13 days [95% CI, 7 to 20 days]). In stage-stratified analyses of 5-year restricted loss in expectation of lifetime, patients with stages I to IIA disease had no noteworthy excess risk of death after they reached EFS24, whereas risk remained measurable for patients with stages IIB to IV cHL.CONCLUSION: Real-world data on young patients with cHL from the Nordic countries show excellent outcomes. The outlook is particularly favorable for patients who reach EFS24, which supports limited relapse-oriented clinical follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (ämneskategori)
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Biccler, Jorne L ...
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Glimelius, Ingri ...
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Eloranta, Sandra
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Smeland, Knut B.
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Brown, Peter de ...
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Jakobsen, Lasse ...
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visa fler...
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Frederiksen, Hen ...
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Jerkeman, Mats
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Fosså, Alexander
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Andersson, There ...
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Holte, Harald
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Bögsted, Martin
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El-Galaly, Tarec ...
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Smedby, Karin E.
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet