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PROTECTIVE EFFECTS ...
PROTECTIVE EFFECTS OF THE COMPLEMENT INHIBITOR COMPSTATIN CP40 IN HEMORRHAGIC SHOCK
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- van Griensven, Martijn (författare)
- Tech Univ Munich, Klinikum Rechts Isar, Dept Trauma Surg, Expt Trauma Surg, Munich, Germany,Technical University of Munich, Germany
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- Ricklin, Daniel (författare)
- Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA;Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland,University of Pennsylvania, USA ; University of Basel, Switzerland
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- Denk, Stephanie (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Halbgebauer, Rebecca (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Braun, Christian K. (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Schultze, Anke (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Hoenes, Felix (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Koutsogiannaki, Sofia (författare)
- Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA,University of Pennsylvania, USA
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- Primikyri, Alexandra (författare)
- Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA,University of Pennsylvania, USA
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- Reis, Edimara (författare)
- Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA,University of Pennsylvania, USA
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- Messerer, David (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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- Hafner, Sebastian (författare)
- Univ Ulm, Inst Anaesthesiol Pathophysiol & Proc Dev, Ulm, Germany,University of Ulm, Germany
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- Radermacher, Peter (författare)
- Univ Ulm, Inst Anaesthesiol Pathophysiol & Proc Dev, Ulm, Germany,University of Ulm, Germany
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- Biglarnia, Ali-Reza (författare)
- Lund Univ, Malmo Univ Hosp, Dept Transplantat, Lund, Sweden,Malmö University Hospital ; Lund University
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- Resuello, Ranillo R. G. (författare)
- Simian Conservat Breeding & Res Ctr SICONBREC, Makati, Philippines,Simian Conservation Breeding and Research Center (SICONBREC), Philippines
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- Tuplano, Joel V. (författare)
- Simian Conservat Breeding & Res Ctr SICONBREC, Makati, Philippines,Simian Conservation Breeding and Research Center (SICONBREC), Philippines
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- Mayer, Benjamin (författare)
- Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany,University of Ulm, Germany
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- Nilsson, Kristina, 1967- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC
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- Nilsson, Bo (författare)
- Uppsala universitet,Klinisk immunologi,Uppsala University, Sweden
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- Lambris, John D. (författare)
- Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA,University of Pennsylvania, USA
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- Huber-Lang, Markus (författare)
- Univ Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany,University of Ulm, Germany
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(creator_code:org_t)
- Alphen aan den Rijn : LIPPINCOTT WILLIAMS & WILKINS, 2019
- 2019
- Engelska.
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Ingår i: Shock. - Alphen aan den Rijn : LIPPINCOTT WILLIAMS & WILKINS. - 1073-2322 .- 1540-0514. ; 51:1, s. 78-87
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Trauma-induced hemorrhagic shock (HS) plays a decisive role in the development of immune, coagulation, and organ dysfunction often resulting in a poor clinical outcome. Imbalanced complement activation is intricately associated with the molecular danger response and organ damage after HS. Thus, inhibition of the central complement component C3 as turnstile of both inflammation and coagulation is hypothesized as a rational strategy to improve the clinical course afterHS. Applying intensive care conditions, anaesthetized, monitored, and protectively ventilated nonhuman primates (NHP; cynomolgusmonkeys) received a pressure-controlled severe HS (60min at mean arterial pressure 30 mmHg) with subsequent volume resuscitation. Thirty minutes after HS, animals were randomly treated with either an analog of the C3 inhibitor compstatin (i.e., Cp40) in saline (n =4) or with saline alone (n =4). The observation period lasted 300 min after induction of HS. We observed improved kidney function in compstatin Cp40-treated animals after HS as determined by improved urine output, reduced damage markers and a tendency of less histopathological signs of acute kidney injury. Sham-treated animals revealed classical signs ofmucosal edema, especially in the ileum and colon reflected by worsened microscopic intestinal injury scores. In contrast, Cp40-treated HS animals exhibited only minor signs of organ edema and significantly less intestinal damage. Furthermore, early systemic inflammation and coagulation dysfunction were both ameliorated by Cp40. The data suggest that therapeutic inhibition of C3 is capable to significantly improve immune, coagulation, and organ function and to preserve organ-barrier integrity early after traumatic HS. C3-targeted complement inhibition may therefore reflect a promising therapeutic strategy in fighting fatal consequences of HS.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- Complement
- hemorrhagic shock
- inflammation
- intestine
- kidney
- nonhuman primate
- Immunologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Shock
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Till lärosätets databas
- Av författaren/redakt...
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van Griensven, M ...
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Ricklin, Daniel
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Denk, Stephanie
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Halbgebauer, Reb ...
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Braun, Christian ...
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Schultze, Anke
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Hoenes, Felix
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Koutsogiannaki, ...
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Primikyri, Alexa ...
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Reis, Edimara
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Messerer, David
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Hafner, Sebastia ...
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Radermacher, Pet ...
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Biglarnia, Ali-R ...
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Resuello, Ranill ...
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Tuplano, Joel V.
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Mayer, Benjamin
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Nilsson, Kristin ...
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Nilsson, Bo
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Lambris, John D.
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Huber-Lang, Mark ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
- Artiklar i publikationen
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Shock
- Av lärosätet
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Uppsala universitet
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Linnéuniversitetet