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The anti-inflammato...
The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation
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- Miao, Lingchao (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Tao, Hongxun (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Peng, Yu (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Wang, Shengpeng (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Zhong, Zhangfeng (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi
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- Dragan, Simona (författare)
- Univ Med & Farm Timisoara, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
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- Zengin, Gokhan (författare)
- Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey
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- Cheang, Wai San (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Wang, Yitao (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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- Xiao, Jianbo (författare)
- Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2019
- 2019
- Engelska.
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Ingår i: Food Chemistry. - : ELSEVIER SCI LTD. - 0308-8146 .- 1873-7072. ; 290, s. 239-245
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Portulaca oleracea L. (Purslane) has great potential as food and traditional drugs in several countries. The purpose of this study was to evaluate the anti-inflammatory effects of purslane extract on lipopolysaccharide (LPS)stimulated RAW 264.7 cells. Purslane extracts significantly reduced LPS-induced synthesis of NO in a dose-dependent manner, as well as the expression levels of iNOS and COX-2. The productions of TNF-alpha and IL-6 were also significantly reduced at the higher dose of 400 mu g/ml. Meanwhile, the expression levels of P65, p-P65, p-MEK and p-I kappa B-alpha were inhibited dose-dependently. The nuclear translocation of P65 was partially prevented by the extract, which explained the inhibition of NF-kappa B pathway. In addition, three reported flavonoids, named luteolin, kaempferol and quercitrin, were identified in the extract, which might be responsible for its anti-inflammatory effects. Above all, our research has partially proved that purslane could be considered as a natural anti-inflammatory agent in further applications.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Portulaca oleracea L.
- Flavonoids
- Lipopolysaccharide
- Anti-inflammatory effects
- NF-kappa B
- MAPK
Publikations- och innehållstyp
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Miao, Lingchao
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Tao, Hongxun
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Peng, Yu
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Wang, Shengpeng
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Zhong, Zhangfeng
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El-Seedi, Hesham
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visa fler...
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Dragan, Simona
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Zengin, Gokhan
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Cheang, Wai San
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Wang, Yitao
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Xiao, Jianbo
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
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Food Chemistry
- Av lärosätet
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Uppsala universitet