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Definitions and gui...
Definitions and guidelines for research on antibiotic persistence
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- Balaban, Nathalie Q. (författare)
- Hebrew Univ Jerusalem, Racah Inst Phys, Jerusalem, Israel
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- Helaine, Sophie (författare)
- Imperial Coll London, MRC Ctr Mol Bacteriol & Infect, London, England
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- Lewis, Kim (författare)
- Northeastern Univ, Dept Biol, Boston, MA 02115 USA
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- Ackermann, Martin (författare)
- Swiss Fed Inst Technol, Inst Biogeochem & Pollutant Dynam, Zurich, Switzerland;Eawag, Dept Environm Microbiol, Dubendorf, Switzerland
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- Aldridge, Bree (författare)
- Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
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- Andersson, Dan I (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Brynildsen, Mark P. (författare)
- Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA
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- Bumann, Dirk (författare)
- Univ Basel, Biozentrum, Focal Area Infect Biol, Basel, Switzerland
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- Camilli, Andrew (författare)
- Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
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- Collins, James J. (författare)
- MIT, Dept Biol Engn, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA;MIT, Synthet Biol Ctr, 77 Massachusetts Ave, Cambridge, MA 02139 USA;Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Cambridge, MA USA
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- Dehio, Christoph (författare)
- Univ Basel, Biozentrum, Focal Area Infect Biol, Basel, Switzerland
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- Fortune, Sarah (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA
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- Ghigo, Jean-Marc (författare)
- Inst Pasteur, Genet Biofilms Lab, Paris, France
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- Hardt, Wolf-Dietrich (författare)
- Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland
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- Harms, Alexander (författare)
- Univ Basel, Biozentrum, Focal Area Infect Biol, Basel, Switzerland
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- Heinemann, Matthias (författare)
- Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Mol Syst Biol, Groningen, Netherlands
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- Hung, Deborah T. (författare)
- Broad Inst MIT & Harvard, Cambridge, MA USA
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- Jenal, Urs (författare)
- Univ Basel, Biozentrum, Focal Area Infect Biol, Basel, Switzerland
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- Levin, Bruce R. (författare)
- Emory Univ, Dept Biol, Atlanta, GA 30322 USA
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- Michiels, Jan (författare)
- Univ Leuven, KU Leuven, Ctr Microbiol, Leuven, Belgium
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- Storz, Gisela (författare)
- Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Mol & Cellular Biol, Bethesda, MD USA
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- Tan, Man-Wah (författare)
- Genentech Inc, Infect Dis Dept, San Francisco, CA USA
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- Tenson, Tanel (författare)
- Univ Tartu, Inst Technol, Tartu, Estonia
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- Van Melderen, Laurence (författare)
- Univ Libre Bruxelles, Fac Sci, Brussels, Belgium
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- Zinkernagel, Annelies (författare)
- Univ Zurich, Univ Hosp Zurich, Div Infect Dis, Zurich, Switzerland
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(creator_code:org_t)
- 2019-04-12
- 2019
- Engelska.
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Ingår i: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 17:7, s. 441-448
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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Balaban, Nathali ...
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Helaine, Sophie
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Lewis, Kim
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Ackermann, Marti ...
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Aldridge, Bree
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Andersson, Dan I
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visa fler...
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Brynildsen, Mark ...
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Bumann, Dirk
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Camilli, Andrew
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Collins, James J ...
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Dehio, Christoph
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Fortune, Sarah
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Ghigo, Jean-Marc
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Hardt, Wolf-Diet ...
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Harms, Alexander
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Heinemann, Matth ...
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Hung, Deborah T.
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Jenal, Urs
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Levin, Bruce R.
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Michiels, Jan
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Storz, Gisela
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Tan, Man-Wah
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Tenson, Tanel
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Van Melderen, La ...
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Zinkernagel, Ann ...
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