Sökning: onr:"swepub:oai:DiVA.org:uu-390826" > Endothelial cell cl...
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000 | 04566naa a2200493 4500 | |
001 | oai:DiVA.org:uu-390826 | |
003 | SwePub | |
008 | 190814s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3908262 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-10707-x2 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Malinverno, Matteou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
245 | 1 0 | a Endothelial cell clonal expansion in the development of cerebral cavernous malformations |
264 | c 2019-06-24 | |
264 | 1 | b NATURE PUBLISHING GROUP,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes. Familial CCM follows a two-hit mechanism similar to that of tumour suppressor genes, while in sporadic cavernomas only a small fraction of endothelial cells shows mutated CCM genes. We reported that in mouse models and in human patients, endothelial cells lining the lesions have different features from the surrounding endothelium, as they express mesenchymal/stem-cell markers. Here we show that cavernomas originate from clonal expansion of few Ccm3-null endothelial cells that express mesenchymal/stem-cell markers. These cells then attract surrounding wild-type endothelial cells, inducing them to express mesenchymal/stem-cell markers and to contribute to cavernoma growth. These characteristics of Ccm3-null cells are reminiscent of the tumour-initiating cells that are responsible for tumour growth. Our data support the concept that CCM has benign tumour characteristics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Maderna, Claudiou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Abu Taha, Abdallahu Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)abdab543 |
700 | 1 | a Corada, Monicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Orsenigo, Fabriziou FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Valentino, Mariaelenau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Pisati, Federicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Cogentech Scarl, Histopathol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Fusco, Carmelau Fdn IRCCS Casa Sollievo Sofferenza, Div Med Genet, I-71013 Foggia, Italy4 aut |
700 | 1 | a Graziano, Paolou Fdn IRCCS Casa Sollievo Sofferenza, Pathol Unit, I-71013 Foggia, Italy4 aut |
700 | 1 | a Giannotta, Monicau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy4 aut |
700 | 1 | a Yu, Qing Cissyu Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China4 aut |
700 | 1 | a Zeng, Yi Arialu Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China4 aut |
700 | 1 | a Lampugnani, Maria Graziau FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Mario Negri Inst Pharmacol Res, I-20156 Milan, Italy4 aut |
700 | 1 | a Magnusson, Peetra U.u Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)petrmagn |
700 | 1 | a Dejana, Elisabettau Uppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Univ Milan, Sch Med, Dept Oncol & Haematooncol, I-20122 Milan, Italy4 aut0 (Swepub:uu)elide443 |
710 | 2 | a FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italyb Vaskulärbiologi4 org |
773 | 0 | t Nature Communicationsd : NATURE PUBLISHING GROUPg 10q 10x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-019-10707-xy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1342897/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41467-019-10707-x.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390826 |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-10707-x |
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