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c-MET as a biomarke...
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Tsakonas, GeorgiosKarolinska Institutet
(författare)
c-MET as a biomarker in patients with surgically resected non-small cell lung cancer
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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Elsevier,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-390909
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390909URI
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https://doi.org/10.1016/j.lungcan.2019.04.028DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141286925URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: c-MET protein overexpression has been proposed as a biomarker in non-small cell lung cancer (NSCLC), albeit its role in the clinical setting has not been firmly established yet. Patients and methods: We designed a retrospective cohort study, consisting of 725 patients with surgically removed NSCLC. Immunohistochemistry (IHC) was conducted in tissue microarrays (TMA) from lung tumors and healthy tissue. IHC staining was quantified using H-scores (range 0-300). Association between c-MET H-score and overall survival (OS) as well as progression-free survival (PFS) was explored. Results: c-MET H-score >= 20 had a significant positive impact on OS in the multivariate analysis in the whole study population, HR = 0.79 (95%CI: 0.64 - 0.97). The prognostic effect of c-MET H-score >= 20 was even stronger in patients who received adjuvant treatment with a HR = 0.61 (95% CI: 0.40 - 0.93). In the subgroup of adenocarcinoma and squamous cell carcinoma patients with stage IIA-IIIB disease, the prognostic impact of c-MET was significant in the univariate analysis (HR = 0.60, 95% CI: 0.43 - 0.83). Conclusion: c-MET H-score >= 20 is a positive prognostic biomarker for OS in early stage NSCLC. This benefit seems to be strongly correlated to adjuvant chemotherapy, therefore rendering c-MET H-score >= 20 a possible predictive biomarker for platinum-based adjuvant chemotherapy in early stage NSCLC.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Botling, JohanUppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)johanbot
(författare)
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Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Patrick Micke(Swepub:uu)patmi676
(författare)
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Rivard, ChrisUniv Colorado, Div Med Oncol, Anschutz Med Campus, Aurora, CO USA
(författare)
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La Fleur, LinneaUppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)linla513
(författare)
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Mattsson, Johanna Sofia Margareta,1985-Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke(Swepub:uu)johma961
(författare)
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Boyle, TeresaUniv Colorado, Div Med Oncol, Anschutz Med Campus, Aurora, CO USA
(författare)
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Hirsch, Fred R.Univ Colorado, Div Med Oncol, Anschutz Med Campus, Aurora, CO USA
(författare)
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Ekman, SimonKarolinska Institutet
(författare)
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Karolinska InstitutetKlinisk och experimentell patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lung Cancer: Elsevier133, s. 69-740169-50021872-8332
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