SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-392574"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-392574" > Increased Inflammat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005819naa a2200553 4500
001oai:DiVA.org:uu-392574
003SwePub
008190910s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141455786
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3925742 URI
0247 a https://doi.org/10.1373/clinchem.2018.3010852 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1414557862 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hjort, Marcusu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)marhj595
2451 0a Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries
264 c 2019-08-01
264 1b AMER ASSOC CLINICAL CHEMISTRY,c 2019
338 a print2 rdacarrier
520 a BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts. 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
7001 a Eggers, Kai M.,d 1962-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)kaieg561
7001 a Lindhagen, Larsu Karolinska Institutet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)lla11670
7001 a Agewall, Stefanu Karolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo Univ Hosp, Oslo, Norway4 aut
7001 a Brolin, Elin B.u Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci Intervent & Technol, Stockholm, Sweden4 aut
7001 a Collste, Olovu Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut
7001 a Daniel, Mariau Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut
7001 a Ekenbäck, Christinau Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut
7001 a Frick, Matsu Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut
7001 a Henareh, Loghmanu Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden4 aut
7001 a Hofman-Bang, Claesu Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut
7001 a Malmqvist, Karinu Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut
7001 a Spaak, Jonasu Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut
7001 a Sörensson, Pederu Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden4 aut
7001 a Y-Hassan, Shamsu Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden4 aut
7001 a Tornvall, Peru Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut
7001 a Lindahl, Bertil,d 1957-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)belin227
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Clinical Chemistryd : AMER ASSOC CLINICAL CHEMISTRYg 65:8, s. 1023-1030q 65:8<1023-1030x 0009-9147x 1530-8561
8564 u https://academic.oup.com/clinchem/article-pdf/65/8/1023/32638731/clinchem1023.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392574
8564 8u https://doi.org/10.1373/clinchem.2018.301085
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141455786

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy