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Biochemical Inhibit...
Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro
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- Frobom, Robin (författare)
- Karolinska Institutet
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- Sellberg, Felix (författare)
- Uppsala universitet,Klinisk immunologi
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- Xu, Cheng (författare)
- Karolinska Inst, Rolf Luft Ctr Diabet Res, Dept Mol Med & Surg, Stockholm, Sweden
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- Zhao, Allan (författare)
- Karolinska Inst, Rolf Luft Ctr Diabet Res, Dept Mol Med & Surg, Stockholm, Sweden
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- Larsson, Catharina (författare)
- Karolinska Institutet
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- Lui, Wenn-Onn (författare)
- Karolinska Institutet
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- Nilsson, Inga-Lena (författare)
- Karolinska Institutet
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- Berglund, Erik (författare)
- Karolinska Institutet
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- Branstrom, Robert (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-07-01
- 2019
- Engelska.
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Ingår i: Anticancer Research. - : INT INST ANTICANCER RESEARCH. - 0250-7005 .- 1791-7530. ; 39:7, s. 3433-3442
- Relaterad länk:
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http://ar.iiarjourna...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background/Aim: DOG1 is a calcium-activated chloride channel that has gained attention as a promising drug target due to its involvement in several processes essential for tumor development and progression. DOG1 is overexpressed in >95% of gastrointestinal stromal tumors (GIST). The aim was to determine DOG1 inhibition antitumoral effects on GIST. Materials and Methods: Human GIST (GIST-T1 and GIST882) cell lines were used to study the effect of DOG1 inhibitors on chloride currents, viability, colony formation, and cell cycle. Results: CaCCinh-A01 decreased chloride currents. CaCCinh-A01 and T16(inh)-A01 reduced GIST cell viability and CaCCinh-A01 affected cell cycle distribution leading to G(1) cell-cycle arrest. CaCCinh-A01 also increased the sub-G(1) phase population, indicative of apoptosis, in GIST882. CaCCinh-A01 strongly reduced the colony forming ability of the cells, whereas T16(inh)-A01 did not. Conclusion: DOG1 inhibition has antitumoral effects in GIST cells in vitro, and could potentially serve as a target for GIST therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Gastrointestinal stromal tumors
- GIST
- DOG1
- TMEM16A
- ion channel
- cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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