Sökning: onr:"swepub:oai:DiVA.org:uu-394646" > Coagulation Factor ...
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000 | 07314naa a2200745 4500 | |
001 | oai:DiVA.org:uu-394646 | |
003 | SwePub | |
008 | 191017s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3946462 URI |
024 | 7 | a https://doi.org/10.3390/cancers110811032 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Arce, Maximilianou Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile4 aut |
245 | 1 0 | a Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation |
264 | c 2019-08-02 | |
264 | 1 | b MDPI,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human tumors and the experimental metastasis of the B16F10 melanoma in mouse models. FXa increased solid tumor volume and lung, liver, kidney and lymph node metastasis of tail-vein injected B16F10 cells. Concentrating on the metastasis model, upon coadministration of the anticoagulant Dalteparin, lung metastasis was significantly reduced, and no metastasis was observed in other organs. FXa did not directly alter proliferation, migration or invasion of cancer cells in vitro. Alternatively, FXa upon endothelial cells promoted cytoskeleton contraction, disrupted membrane VE-Cadherin pattern, heightened endothelial-hyperpermeability, increased inflammatory adhesion molecules and enhanced B16F10 adhesion under flow conditions. Microarray analysis of endothelial cells treated with FXa demonstrated elevated expression of inflammatory transcripts. Accordingly, FXa treatment increased immune cell infiltration in mouse lungs, an effect reduced by dalteparin. Taken together, our results suggest that FXa increases B16F10 metastasis via endothelial cell activation and enhanced cancer cell-endothelium adhesion advocating that the coagulation system is not merely a bystander in the process of cancer metastasis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a cancer | |
653 | a metastasis | |
653 | a melanoma | |
653 | a blood coagulation | |
653 | a vascular endothelium | |
653 | a inflammation | |
700 | 1 | a Pinto, Mauricio P.u Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut |
700 | 1 | a Galleguillos, Macarenau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Munoz, Catalinau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Lange, Soledadu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Ramirez, Carolinau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Erices, Rafaelau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Univ Mayor, Vicerrectoria Invest, Santiago 7510041, Chile4 aut |
700 | 1 | a Gonzalez, Pamelau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Velasquez, Ethelu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Comis Chilena Energia Nucl CCHEN, Santiago, Chile4 aut |
700 | 1 | a Tempio, Fabianu Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile4 aut |
700 | 1 | a Lopez, Mercedes N.u Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut |
700 | 1 | a Salazar-Onfray, Flaviou Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut |
700 | 1 | a Cautivo, Kellyu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Kalergis, Alexis M.u Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Biomed Res Consortium Chile, Santiago 8331010, Chile4 aut |
700 | 1 | a Cruz, Sebastianu Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile4 aut |
700 | 1 | a Lladser, Alvarou Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile4 aut |
700 | 1 | a Lobos-Gonzalez, Lorenau Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile;Univ Desarrollo, Fac Med, Regenerat Med Ctr, Clin Alemana, Santiago 7650568, Chile4 aut |
700 | 1 | a Valenzuela, Guillermou Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut |
700 | 1 | a Olivares, Nixau Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut |
700 | 1 | a Saez, Claudiau Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut |
700 | 1 | a Koning, Taniau Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile4 aut |
700 | 1 | a Sanchez, Fabiola A.u Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile4 aut |
700 | 1 | a Fuenzalida, Patriciau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut |
700 | 1 | a Godoy, Alejandrou Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Roswell Pk Comprehens Canc Ctr, Dept Urol, Buffalo, NY 14203 USA4 aut |
700 | 1 | a Contreras Orellana, Pamelau Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut |
700 | 1 | a Leyton, Lisetteu Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut |
700 | 1 | a Lugano, Robertau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)roblu911 |
700 | 1 | a Dimberg, Annau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)annadimb |
700 | 1 | a Quest, Andrew F. G.u Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut |
700 | 1 | a Owen, Gareth, Iu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut |
710 | 2 | a Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chileb Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 org |
773 | 0 | t Cancersd : MDPIg 11:8q 11:8x 2072-6694 |
856 | 4 | u https://doi.org/10.3390/cancers11081103y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1362010/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.mdpi.com/2072-6694/11/8/1103/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394646 |
856 | 4 8 | u https://doi.org/10.3390/cancers11081103 |
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