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Hepatic oxygen cons...
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Rasmussen, I
(författare)
Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
- Artikel/kapitelEngelska1993
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LIBRIS-ID:oai:DiVA.org:uu-395087
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395087URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE: To study hepatic oxygen consumption and cytochrome P450 activity in pigs with septic shock induced by faecal peritonitis.DESIGN: Controlled experimental study.ANIMALS: 12 pigs weighing 19-27 kg.INTERVENTION: The animals were divided into a control group (n = 6) and a peritonitis group (n = 6). Peritonitis was induced by intraperitoneal instillation of a standard amount of autologous faeces. The animals were then observed for 300 minutes. Liver biopsy specimens were taken at 0 and 300 minutes.MAIN OUTCOME MEASURES: Hepatic oxygen delivery (DO2) and consumption (VO2). Cytochrome P450 activity was studied by measuring O- and N-demethylation of codeine at 0 and 300 minutes.RESULTS: Hepatic DO2 was reduced, whereas VO2 was increased during sepsis. There were no significant changes in the N- and O-demethylation of codeine.CONCLUSIONS: Hepatic VO2 did increase during sepsis, possibly because of the increased metabolic demand. Cytochrome P450 activity was unaffected by the septic challenge.
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Rane, A
(författare)
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Haglund, U
(författare)
Sammanhörande titlar
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Ingår i:European Journal of Surgery159:4, s. 201-71102-41511741-9271
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