Sökning: onr:"swepub:oai:DiVA.org:uu-396188" > Computational model...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04516naa a2200517 4500 | |
001 | oai:DiVA.org:uu-396188 | |
003 | SwePub | |
008 | 191030s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141036703 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3961882 URI |
024 | 7 | a https://doi.org/10.1080/10408444.2019.15841532 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410367032 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Ganguly, Koustavu Karolinska Institutet4 aut |
245 | 1 0 | a Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients :b identification of gaps in knowledge and data |
264 | c 2019-04-23 | |
264 | 1 | b TAYLOR & FRANCIS LTD,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Computational modeling together with experimental data are essential to assess the risk for particulate matter mediated lung toxicity and to predict the efficacy, safety and fate of aerosolized drug molecules used in inhalation therapy. In silico models are widely used to understand the deposition, distribution, and clearance of inhaled particles and aerosols in the human lung. Exacerbations of chronic obstructive pulmonary disease (COPD) have been reported due to increased particulate matter related air pollution episodes. Considering the profound functional, anatomical and structural changes occurring in COPD lungs, the relevance of the existing in silico models for mimicking diseased lungs warrants reevaluation. Currently available computational modeling tools were developed for the healthy adult (male) lung. Here, we analyze the major alterations occurring in the airway structure, anatomy and pulmonary function in the COPD lung, as compared to the healthy lung. We also scrutinize the various physiological and particle characteristics that influence particle deposition, distribution and clearance in the lung. The aim of this review is to evaluate the availability of the fundamental knowledge and data required for modeling particle deposition in a COPD lung departing from the existing healthy lung models. The extent to which COPD pathophysiology may affect aerosol deposition depends on the relative contribution of several factors such as altered lung structure and function, bronchoconstriction, emphysema, loss of elastic recoil, altered breathing pattern and altered liquid volumes that warrant consideration while developing physiologically relevant in silico models. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a Emphysema | |
653 | a chronic bronchitis | |
653 | a air pollution | |
653 | a inhalation | |
653 | a particle | |
653 | a COPD | |
653 | a in silico | |
700 | 1 | a Carlander, Ulrikau Karolinska Institutet4 aut |
700 | 1 | a Garessus, Estella D. G.u Karolinska Inst, Inst Environm Med, Integrat Toxicol, Stockholm, Sweden4 aut |
700 | 1 | a Fridén, Markusu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,AstraZeneca, Resp Inflammat & Autoimmun IMED Biotech Unit, Gothenburg, Sweden4 aut0 (Swepub:uu)mafri535 |
700 | 1 | a Eriksson, Ulf G.u AstraZeneca, Quantitat Clin Pharmacol, IMED Biotech Unit, Early Clin Dev, Gothenburg, Sweden4 aut |
700 | 1 | a Tehler, Ulrikau AstraZeneca, IMED Biotech Unit, Early Prod Dev, Pharmaceut Sci, Gothenburg, Sweden4 aut |
700 | 1 | a Johanson, Gunnaru Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Inst Environm Med, Integrat Toxicol, Stockholm, Sweden4 org |
773 | 0 | t Critical reviews in toxicologyd : TAYLOR & FRANCIS LTDg 49:2, s. 160-173q 49:2<160-173x 1040-8444x 1547-6898 |
856 | 4 | u https://doi.org/10.1080/10408444.2019.1584153y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1366793/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.tandfonline.com/doi/pdf/10.1080/10408444.2019.1584153?needAccess=true |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396188 |
856 | 4 8 | u https://doi.org/10.1080/10408444.2019.1584153 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141036703 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy