SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-396630"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-396630" > Impact of T Cell Do...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00011801naa a2201117 4500
001oai:DiVA.org:uu-396630
003SwePub
008191108s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:142003911
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3966302 URI
0247 a https://doi.org/10.1016/j.bbmt.2019.05.0072 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1420039112 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saad, Aymanu Ohio State Univ, Div Hematol, Columbus, OH 43210 USA4 aut
2451 0a Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
264 1b ELSEVIER SCIENCE INC,c 2019
338 a print2 rdacarrier
520 a Data on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transplantation for acute leukemia or myelodysplastic syndrome between 2008 and 2014 using an HLA-matched sibling donor (MSD) or an 8/8-matched unrelated donor (MUD). We excluded ex vivo and in vivo T cell-depleted transplantations. Correlative analysis was performed between CD3(+) T cell dose and the risk of graft-versus-host-disease (GVHD), relapse, nonrelapse mortality (NRM), disease-free survival (DFS), and overall survival (OS). Using maximum likelihood estimation, we identified CD3(+) T cell dose cutoff that separated the risk of acute GVHD (aGVHD) grade II-IV in both the MSD and MUD groups. A CD3(+) T cell dose cutoff of 14 x 10(7) cells/kg identified MSD/low CD3(+) (n = 223) and MSD/high CD3(+) (n = 1214), and a dose of 15 x 107 cells/kg identified MUD/low (n = 197) and MUD/high CD3(+) (n = 1102). On univariate analysis, the MSD/high CD3(+) group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MSD/low CD3(+) group (33% versus 25%; P=.009). There were no differences between the 2 groups in engraftment rate, risk of aGVHD grade III-IV or chronic GVHD (cGVHD), NRM, relapse, DFS, or OS. The MUD/high CD3(+) group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MUD/low CD3(+) group (49% versus 41%; P=.04). There were no differences between the 2 groups in engraftment rate, risk of severe aGVHD or cGVHD, NRM, relapse, DFS, or OS. Multivariate analysis of the MSD and MUD groups failed to show an association between CD3(+) T cell dose and the risk of either aGVHD grade II-IV (P=.10 and .07, respectively) or cGVHD (P = .80 and .30, respectively). Subanalysis of CD4(+) T cells, CD8(+) T cells, and CD4+/CD8+ ratio failed to identify cutoff values predictive of transplantation outcomes; however, using the log-rank test, the sample size was suboptimal for identifying a difference at this cutoff cell dose. In this registry study, the CD3(+) T cell dose of PBSC products did not influence the risk of aGVHD or cGVHD or other transplantation outcomes when using an MSD or an 8/8-matched MUD. Subset analyses of CD4(+) and CD8(+) T cell doses were not possible given our small sample size. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653 a T cell
653 a GVHD dose
653 a Allogeneic
653 a Transplantation
7001 a Lamb, Lawrenceu Univ Alabama Birmingham, Birmingham, AL USA4 aut
7001 a Wang, Taou Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA4 aut
7001 a Hemmer, Michael T.u Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA4 aut
7001 a Spellman, Stephenu Natl Marrow Donor Program Match, Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA4 aut
7001 a Couriel, Danielu Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA4 aut
7001 a Alousi, Aminu Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Stem Cell Transplantat, Houston, TX 77030 USA4 aut
7001 a Pidala, Josephu H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USA4 aut
7001 a Abdel-Azim, Hishamu Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90033 USA4 aut
7001 a Agrawall, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA4 aut
7001 a Aljurf, Mahmoudu King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia4 aut
7001 a Beitinjaneh, Amer M.u Univ Miami, Miami, FL USA4 aut
7001 a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA4 aut
7001 a Buchbinder, Davidu Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA4 aut
7001 a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Div Hematol Oncol, Nashville, TN USA4 aut
7001 a Cahn, Jean -Yvesu CHU Grenoble Alpes, Dept Hematol, Grenoble, France4 aut
7001 a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY USA4 aut
7001 a Castillo, Paulu UF Hlth Shands Childrens Hosp, Gainesville, FL USA4 aut
7001 a Chhabra, Saurabhu Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA4 aut
7001 a Angel Diaz, Miguelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain4 aut
7001 a Farhan, Shathau Henry Ford Hosp, Bone Marrow Transplant Program, Detroit, MI 48202 USA4 aut
7001 a Floisand, Yngvaru Natl Hosp, Oslo, Denmark4 aut
7001 a Frangoul, Hadar A.u Childrens Hosp, TriStar Centennial & Sarah Cannon Res Inst, Nashville, TN USA4 aut
7001 a Gadalla, Shahinaz M.u NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Rockville, MD USA4 aut
7001 a Gajewski, Jamesu Lu Daopei Hosp, Beijing, Peoples R China4 aut
7001 a Gale, Robert Peteru Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England4 aut
7001 a Gandhi, Manishu Mayo Clin, Div Transfus Med, Rochester, MN USA4 aut
7001 a Gergis, Usamau Weill Cornell Med Ctr, New York Presbyterian Hosp, Dept Med Oncol, Hematol Malignancies & Bone Marrow Transplant, New York, NY USA4 aut
7001 a Hamilton, Betty Kyu Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA4 aut
7001 a Hematti, Peimanu Univ Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA4 aut
7001 a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA4 aut
7001 a Kamble, Rammurti T.u Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA4 aut
7001 a Kanate, Abraham S.u West Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA4 aut
7001 a Khandelwal, Poojau Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA4 aut
7001 a Lazaryn, Aleksandru H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USA4 aut
7001 a MacMillan, Margaretu Univ Minnesota, Blood & Marrow Transplant Program, Pediat, Minneapolis, MN USA4 aut
7001 a Marks, David I.u Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England4 aut
7001 a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain4 aut
7001 a Mehta, Parinda A.u Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA4 aut
7001 a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USA4 aut
7001 a Olsson, Richardu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm4 aut0 (Swepub:uu)riols677
7001 a Pate, Sagar S.u Cleveland Clin Fdn, Blood & Marrow Transplant Program, 9500 Euclid Ave, Cleveland, OH 44195 USA4 aut
7001 a Qayed, Munau Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA4 aut
7001 a Rangarajan, Hemalatha G.u Nationwide Childrens Hosp, Dept Pediat Hematol Oncol Blood & Marrow Transpla, Columbus, OH USA4 aut
7001 a Reshef, Ranu Columbia Univ, Med Ctr, Blood & Marrow Transplantat Program, New York, NY USA;Columbia Univ, Med Ctr, Columbia Centerfor Translat Immunobiol, New York, NY USA4 aut
7001 a Ringden, E.u Karolinska Inst, Translat Cell Therapy Res, Stockholm, Sweden4 aut
7001 a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Div Hematol Oncol, Nashville, TN USA4 aut
7001 a Schouten, Harry C.u Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands4 aut
7001 a Schultz, Kirk R.u Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada4 aut
7001 a See, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan4 aut
7001 a Shaffer, Brian C.u Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA4 aut
7001 a Solh, Melhemu Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA4 aut
7001 a Teshima, Takanoriu Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan4 aut
7001 a Urbano-Ispizua, Alvarou Univ Barcelona, Hosp Clin, Dept Hematol, IDIBAPS, Barcelona, Spain;Josep Carreras Inst Res, Barcelona, Spain4 aut
7001 a Verdonck, Leo F.u Isola Clin, Dept Hematol Oncol, Zwolle, Netherlands4 aut
7001 a Vij, Raviu Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA4 aut
7001 a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA4 aut
7001 a William, Basemu Ohio State Univ, Div Hematol, Columbus, OH 43210 USA4 aut
7001 a Wirk, Baldeepu Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA4 aut
7001 a Yared, Jean A.u Univ Maryland, Dept Med, Blood & Marrow Transplantat Program, Greenebaum Comprehens Canc Ctr,Div Hematol Oncol, Baltimore, MD 21201 USA4 aut
7001 a Yu, Lolie C.u Louisiana State Univ, Med Ctr, Div Hematol Oncol & HSCT, Ctr Canc & Blood Disorders,Childrens Hosp, New Orleans, LA 70112 USA4 aut
7001 a Arora, Muktau Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA4 aut
7001 a Hashmi, Shahrukhu King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia;Mayo Clin, Dept Internal Med, Rochester, MN USA4 aut
7102 a Ohio State Univ, Div Hematol, Columbus, OH 43210 USAb Univ Alabama Birmingham, Birmingham, AL USA4 org
7730 t Biology of blood and marrow transplantationd : ELSEVIER SCIENCE INCg 25:9, s. 1875-1883q 25:9<1875-1883x 1083-8791x 1523-6536
8564 u http://www.bbmt.org/article/S1083879119302915/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396630
8564 8u https://doi.org/10.1016/j.bbmt.2019.05.007
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142003911

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy