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Shared Genetic Risk...
Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions
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- Nicoletti, Paola (författare)
- Icahn Sch Med Mt Sinai, New York, NY 10029 USA;Sema4, Stamford, CT USA
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- Barrett, Sarah (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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- McEvoy, Laurence (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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- Daly, Ann K. (författare)
- Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
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- Aithal, Guruprasad (författare)
- Nottingham Univ Hosp NHS Trust, Nottingham Biomed Res Unit, NIHR, Nottingham, England;Univ Nottingham, Nottingham, England
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- Isabel Lucena, M. (författare)
- Univ Malaga, UGC Digest, Clin Pharmacol Serv, Inst Invest Biomed Malaga IBIMA,Hosp Univ Virgen, Malaga, Spain;Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
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- Andrade, Raul J. (författare)
- Univ Malaga, UGC Digest, Clin Pharmacol Serv, Inst Invest Biomed Malaga IBIMA,Hosp Univ Virgen, Malaga, Spain;Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
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- Wadelius, Mia (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk farmakogenomik och osteoporos
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- Hallberg, Pär, 1974- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk farmakogenomik och osteoporos
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- Stephens, Camilla (författare)
- Univ Malaga, UGC Digest, Clin Pharmacol Serv, Inst Invest Biomed Malaga IBIMA,Hosp Univ Virgen, Malaga, Spain;Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
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- Bjornsson, Einar S. (författare)
- Landspitali Univ Hosp, Dept Internal Med, Reykjavik, Iceland
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- Friedmann, Peter (författare)
- Univ Southampton, Sch Med, Dermatol Unit, Southampton, Hants, England
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- Kainu, Kati (författare)
- Univ Helsinki, Cent Hosp, Clin Res Unit Pulm Dis, Helsinki, Finland
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- Laitinen, Tarja (författare)
- Univ Helsinki, Cent Hosp, Clin Res Unit Pulm Dis, Helsinki, Finland
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- Marson, Anthony (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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- Molokhia, Mariam (författare)
- Kings Coll London, Sch Populat Sci & Hlth Serv Res, London, England
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- Phillips, Elizabeth (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
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- Pichler, Werner (författare)
- ADR AC GmbH, Bern, Switzerland
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- Romano, Antonino (författare)
- Complesso Integrato Columbus, Allergy Unit, Rome, Italy
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- Shear, Neil (författare)
- Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
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- Sills, Graeme (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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- Tanno, Luciana K. (författare)
- Hosp Sirio Libanes, Sao Paulo, Brazil
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- Swale, Ashley (författare)
- Columbia Univ, Dept Syst Biol, New York, NY USA
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- Floratos, Aris (författare)
- Columbia Univ, Dept Syst Biol, New York, NY USA
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- Shen, Yufeng (författare)
- Columbia Univ, Dept Syst Biol, New York, NY USA
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- Nelson, Matthew R. (författare)
- GSK, Target Sci, King Of Prussia, PA USA
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- Watkins, Paul B. (författare)
- Univ N Carolina, Eshelman Sch Pharm, Inst Drug Safety Sci, Chapel Hill, NC 27515 USA
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- Daly, Mark J. (författare)
- Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02115 USA
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- Morris, Andrew P. (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England
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- Alfirevic, Ana (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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- Pirmohamed, Munir (författare)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
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(creator_code:org_t)
- 2019-07-03
- 2019
- Engelska.
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Ingår i: Clinical Pharmacology and Therapeutics. - : John Wiley & Sons. - 0009-9236 .- 1532-6535. ; 106:5, s. 1028-1036
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://ascpt.online...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and Southern European CBZ-SCAR cases and 10,701 population controls and a GWAS on 12 CBZ-DILI cases and 8,438 ethnically matched population controls. HLA-A*31:01 was identified as the strongest genetic predisposing factor for both CBZ-SCAR (odds ratio (OR) = 8.0; 95% CI 4.10-15.80; P = 1.2 x 10(-9)) and CBZ-DILI (OR = 7.3; 95% CI 2.47-23.67; P = 0.0004) in European populations. The association with HLA-A*31:01 in patients with SCAR was mainly driven by hypersensitivity syndrome (OR = 12.9; P = 2.1 x 10(-9)) rather than by Stevens-Johnson syndrome/toxic epidermal necrolysis cases, which showed an association with HLA-B*57:01. We also identified a novel risk locus mapping to ALK only for CBZ-SCAR cases, which needs replication in additional cohorts and functional evaluation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nicoletti, Paola
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Barrett, Sarah
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McEvoy, Laurence
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Daly, Ann K.
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Aithal, Gurupras ...
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Isabel Lucena, M ...
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visa fler...
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Andrade, Raul J.
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Wadelius, Mia
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Hallberg, Pär, 1 ...
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Stephens, Camill ...
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Bjornsson, Einar ...
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Friedmann, Peter
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Kainu, Kati
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Laitinen, Tarja
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Marson, Anthony
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Molokhia, Mariam
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Phillips, Elizab ...
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Pichler, Werner
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Romano, Antonino
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Shear, Neil
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Sills, Graeme
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Tanno, Luciana K ...
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Swale, Ashley
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Floratos, Aris
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Shen, Yufeng
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Nelson, Matthew ...
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Watkins, Paul B.
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Daly, Mark J.
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Morris, Andrew P ...
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Alfirevic, Ana
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Pirmohamed, Muni ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Clinical Pharmac ...
- Av lärosätet
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Uppsala universitet