Sökning: onr:"swepub:oai:DiVA.org:uu-397295" > Association of the ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 08913naa a2200721 4500 | |
001 | oai:DiVA.org:uu-397295 | |
003 | SwePub | |
008 | 191125s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3972952 URI |
024 | 7 | a https://doi.org/10.1093/cvr/cvz0152 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kessler, Thorstenu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
245 | 1 0 | a Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention |
264 | c 2019-02-14 | |
264 | 1 | b OXFORD UNIV PRESS,c 2019 |
338 | a print2 rdacarrier | |
520 | a Aim A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Methods and results The association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry. The clinical outcome cardiovascular death or stent thrombosis within 30 days after stenting was investigated in a meta-analysis of substudies of the ISAR-ASPI registry, the PLATO trial (n = 3236), and the Utrecht Coronary Biobank (n = 1003) comprising a total 5917 patients. Homozygous GUCY1A3 risk allele carriers (GG) displayed increased on-aspirin platelet reactivity compared with non-risk allele (AA/AG) carriers [150 (interquartile range 91-209) vs. 134 (85-194) AU.min, P < 0.01]. More homozygous risk allele carriers, compared with non-risk allele carriers, were assigned to the high-risk group for ischaemic events (>203AU.min; 29.5 vs. 24.2%, P = 0.02). Homozygous risk allele carriers were also at higher risk for cardiovascular death or stent thrombosis (hazard ratio 1.70, 95% confidence interval 1.08-2.68; P = 0.02). Bleeding risk was not altered. Conclusion We conclude that homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity. Whether GUCY1A3 genotype helps to tailor antiplatelet treatment remains to be investigated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a On-aspirin platelet reactivity | |
653 | a Genetic variation | |
653 | a Stent thrombosis | |
653 | a Genome-wide association studies | |
653 | a Platelet aggregation | |
700 | 1 | a Wolf, Bernhardu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Eriksson, Niclas,d 1978-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103 |
700 | 1 | a Kofink, Danielu Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands4 aut |
700 | 1 | a Mahmoodi, Bakhtawar K.u St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands4 aut |
700 | 1 | a Rai, Himanshuu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut |
700 | 1 | a Tragante, Viniciusu Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands4 aut |
700 | 1 | a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)axeak985 |
700 | 1 | a Becker, Richard C.u Univ Cincinnati, Heart Lung & Vasc Inst, Div Cardiovasc Hlth & Dis, Cincinnati, OH USA4 aut |
700 | 1 | a Bernlochner, Isabellu Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany4 aut |
700 | 1 | a Bopp, Romanu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut |
700 | 1 | a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367 |
700 | 1 | a Katus, Hugo A.u Heidelberg Univ, Innere Med Kardiol Angiol & Pneumol 3, Heidelberg, Germany;DZHK eV, Partner Site Heidelberg, Heidelberg, Germany4 aut |
700 | 1 | a Mayer, Katharinau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut |
700 | 1 | a Munz, Matthiasu Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany;Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany4 aut |
700 | 1 | a Nordio, Francescou Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA4 aut |
700 | 1 | a O'Donoghue, Michelle L.u Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA4 aut |
700 | 1 | a Sager, Hendrik B.u Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Sibbing, Dirku Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 1, Munich, Germany4 aut |
700 | 1 | a Solakov, Lindau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut |
700 | 1 | a Storey, Robert F.u Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England4 aut |
700 | 1 | a Wobst, Janau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Asselbergs, Folkert W.u Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands;Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England;UCL, Hlth Data Res UK, London, England;UCL, Inst Hlth Informat, London, England4 aut |
700 | 1 | a Byrne, Robert A.u Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut |
700 | 1 | a Erdmann, Jeanetteu Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany4 aut |
700 | 1 | a Koenig, Wolfgangu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Laugwitz, Karl-Ludwigu Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany4 aut |
700 | 1 | a ten Berg, Jurrien M.u St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands4 aut |
700 | 1 | a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall |
700 | 1 | a Kastrati, Adnanu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Schunkert, Heribertu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut |
710 | 2 | a Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germanyb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Cardiovascular Researchd : OXFORD UNIV PRESSg 115:10, s. 1512-1518q 115:10<1512-1518x 0008-6363x 1755-3245 |
856 | 4 | u https://academic.oup.com/cardiovascres/article-pdf/115/10/1512/28981341/cvz015.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397295 |
856 | 4 8 | u https://doi.org/10.1093/cvr/cvz015 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.