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Associations betwee...
Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank
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- Tan, Xiao (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Ciuculete, Diana-Maria (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia
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- Benedict, Christian, Docent, 1976- (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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(creator_code:org_t)
- 2019-11-06
- 2020
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 287:2, s. 189-196
- Relaterad länk:
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https://doi.org/10.1...
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ObjectiveTo examine the association between the MTNR1B G risk allele, type 2 diabetes (T2D) and chronotype in the UK Biobank.MethodsData from the baseline investigation of the UK Biobank were utilized (n = 337 083 White British; mean age: 56.9 years; 54% women). MTNR1B rs10830963 was directly genotyped [CC (reference group), CG and GG]. Chronotype was divided into four categories: definitely morning (reference group); more morning than evening; more evening than morning; and definitely evening. Logistic regression analyses were performed to estimate odds ratios and 95% confidence intervals (CIs) for T2D, controlling for age, sex and other confounders.ResultsCarriers of the rs10830963 risk allele had a higher risk of T2D [CG vs. CC: OR (95% CI) 1.10 (1.07, 1.15); GG vs. CC: 1.21 (1.14, 1.29)]. Compared with definitely morning chronotype, participants with definitely evening chronotype exhibited the highest risk of T2D [1.25 (1.17, 1.33)]. Despite a nonsignificant interaction between chronotype and the risk allele [0.98 (0.94, 1.01), P = 0.176 for interaction term], we found that definitely evening chronotype (vs. definitely morning) was linked with a higher risk of T2D amongst CC and CG but not GG carriers. Additionally, we saw that the GG genotype (vs. CC) was associated with a higher risk of T2D across all chronotype categories, except for definitely evening.ConclusionOur findings suggest that the MTNR1B G risk allele and late chronotype increase the risk of T2D. The association between late chronotype and higher risk of T2D appears to vary across MTNR1B rs10830963 genotypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- chronotype
- genetic risk
- melatonin receptor 1B polymorphism
- type 2 diabetes
- UK Biobank
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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