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Sökning: onr:"swepub:oai:DiVA.org:uu-399089" > Prevalence and rele...

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FältnamnIndikatorerMetadata
00005394naa a2200553 4500
001oai:DiVA.org:uu-399089
003SwePub
008191216s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3990892 URI
0247 a https://doi.org/10.1007/s11239-019-01938-22 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA;Uppsala Clin Res Ctr, Hammarskjolds Vag 38, S-75185 Uppsala, Sweden4 aut0 (Swepub:uu)axeak985
2451 0a Prevalence and relevance of abnormal glucose metabolism in acute coronary syndromes :b insights from the PLATelet inhibition and patient Outcomes (PLATO) trial
264 c 2019-09-11
264 1b Springer,c 2019
338 a electronic2 rdacarrier
520 a Diabetes mellitus (DM) and abnormal glucose metabolism are associated with cardiovascular (CV) disease. We investigated the prevalence and prognostic importance of dysglycaemia in patients with acute coronary syndromes (ACS) in the PLATelet inhibition and patient Outcomes (PLATO) trial. Diabetes was defined as known diabetes or HbA1c >= 6.5% or non-fasting glucose >= 11.1 mmol/L on admission, prediabetes as HbA1c >= 5.7% but < 6.5%, and no diabetes as HbA1c < 5.7%. The primary endpoint was the composite of CV death, spontaneous myocardial infarction type 1 (sMI) or stroke at 12 months. Multivariable Cox regression models, adjusting for baseline characteristics, and biomarkers NT-proBNP and troponin I, were used to explore the association between glycaemia and outcome. On admission, 16,007 (86.1%) patients had HbA1c and/or glucose levels available and were subdivided into DM 38.5% (6160) (1501 patients had no previous DM diagnosis), prediabetes 38.8% (6210), and no DM 22.7% (3637). Kaplan Meier event rates at 12 months for CV death, sMI or stroke per subgroups were 14.5% (832), 9.0% (522), and 8.5% (293), respectively with multivariable adjusted HRs, versus no diabetes, for diabetes: 1.71 (1.50-1.95) and for prediabetes 1.03 (0.90-1.19). Corresponding event rates for CV death were 6.9% (391), 3.4% (195) and 3.0% (102), respectively, with adjusted HRs for patients with DM of: 1.92 (1.42-2.60) and for prediabetes 1.02 (0.79-1.32). Abnormal glucose metabolism is common in ACS patients, but only patients with definite DM have an increased CV risk, indicating that prediabetes is not immediately associated with worse CV outcomes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Diabetes
653 a Pre-diabetes
653 a Hemoglobin A1C
653 a Acute coronary syndromes
653 a Myocardial infarction
653 a Risk prediction
7001 a Wojdyla, Danielu Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA4 aut
7001 a Steg, Philippe Gabrielu INSERM, U1148, Paris, France;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Paris, France;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France;Imperial Coll, NHLI, ICMS, Royal Brompton Hosp, London, England4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7001 a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Budaj, Andrzeju Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland4 aut
7001 a Katus, Hugo A.u Univ Klinikum Heidelberg, Med Klin, Heidelberg, Germany4 aut
7001 a Himmelmann, Andersu AstraZeneca Res & Dev, Molndal, Sweden4 aut
7001 a Huber, Kurtu Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria;Sigmund Freud Univ, Sch Med, Vienna, Austria4 aut
7001 a Siegbahn, Agneta,d 1947-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi4 aut0 (Swepub:uu)agsie424
7001 a Storey, Robert F.u Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England4 aut
7001 a Becker, Richard C.u Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA;Acad Hlth Ctr, Div Cardiovasc Hlth & Dis, Heart Lung & Vasc Inst, Cincinnati, OH USA4 aut
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Journal of Thrombosis and Thrombolysisd : Springerg 48:4, s. 563-569q 48:4<563-569x 0929-5305x 1573-742X
8564 u https://doi.org/10.1007/s11239-019-01938-2y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1379145/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s11239-019-01938-2.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-399089
8564 8u https://doi.org/10.1007/s11239-019-01938-2

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