Sökning: onr:"swepub:oai:DiVA.org:uu-400822" > The Oxymonad Genome...
Fältnamn | Indikatorer | Metadata |
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000 | 05608naa a2200601 4500 | |
001 | oai:DiVA.org:uu-400822 | |
003 | SwePub | |
008 | 200113s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4008222 URI |
024 | 7 | a https://doi.org/10.1093/molbev/msz1472 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Karnkowska, Annau Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic;Univ Warsaw, Fac Biol, Biol & Chem Res Ctr, Dept Mol Phylogenet & Evolut, Warsaw, Poland4 aut |
245 | 1 0 | a The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion |
264 | c 2019-08-06 | |
264 | 1 | b OXFORD UNIV PRESS,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here, we report an extensive analysis of the M. exilis genome to address this question. Unexpectedly, we find that M. exilis genome structure and content is similar in complexity to other eukaryotes and less "reduced" than genomes of some other protists from the Metamonada group to which it belongs. Furthermore, the predicted cytoskeletal systems, the organization of endomembrane systems, and biosynthetic pathways also display canonical eukaryotic complexity. The only apparent preadaptation that permitted the loss of mitochondria was the acquisition of the SUF system for Fe-S cluster assembly and the loss of glycine cleavage system. Changes in other systems, including in amino acid metabolism and oxidative stress response, were coincident with the loss of mitochondria but are likely adaptations to the microaerophilic and endobiotic niche rather than the mitochondrial loss per se. Apart from the lack of mitochondria and peroxisomes, we show that M. exilis is a fully elaborated eukaryotic cell that is a promising model system in which eukaryotic cell biology can be investigated in the absence of mitochondria. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a amitochondrial eukaryote | |
653 | a cell biology | |
653 | a Monocercomonoides | |
653 | a oxymonads | |
653 | a protist genomics | |
700 | 1 | a Treitli, Sebastian C.u Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
700 | 1 | a Brzon, Ondreju Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
700 | 1 | a Novak, Lukasu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
700 | 1 | a Vacek, Vojtechu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
700 | 1 | a Soukal, Petru Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
700 | 1 | a Barlow, Lael D.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut |
700 | 1 | a Herman, Emily K.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut |
700 | 1 | a Pipaliya, Shweta, Vu Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut |
700 | 1 | a Panek, Tomasu Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut |
700 | 1 | a Zihala, Davidu Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut |
700 | 1 | a Petrzelkova, Romanau Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut |
700 | 1 | a Butenko, Anzhelikau Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic4 aut |
700 | 1 | a Eme, Laurau Uppsala universitet,Institutionen för cell- och molekylärbiologi,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut0 (Swepub:uu)lauem469 |
700 | 1 | a Stairs, Courtney W.u Uppsala universitet,Institutionen för cell- och molekylärbiologi,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut0 (Swepub:uu)coust885 |
700 | 1 | a Roger, Andrew J.u Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada4 aut |
700 | 1 | a Elias, Mareku Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic;Univ Ostrava, Fac Sci, Inst Environm Technol, Ostrava, Czech Republic4 aut |
700 | 1 | a Dacks, Joel B.u Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada4 aut |
700 | 1 | a Hampl, Vladimiru Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 aut |
710 | 2 | a Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic;Univ Warsaw, Fac Biol, Biol & Chem Res Ctr, Dept Mol Phylogenet & Evolut, Warsaw, Polandb Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic4 org |
773 | 0 | t Molecular biology and evolutiond : OXFORD UNIV PRESSg 36:10, s. 2292-2312q 36:10<2292-2312x 0737-4038x 1537-1719 |
856 | 4 | u https://doi.org/10.1093/molbev/msz147y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1384938/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://academic.oup.com/mbe/article-pdf/36/10/2292/30048254/msz147.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400822 |
856 | 4 8 | u https://doi.org/10.1093/molbev/msz147 |
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