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Prognostic impact o...
Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
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- Abdulla, Maysaa (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Guglielmo, Priscilla (författare)
- Uppsala universitet,Radiologi,Brotzu General Hospital, Cagliari, Italy
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- Hollander, Peter (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Åström, Gunnar, 1955- (författare)
- Uppsala universitet,Radiologi
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi
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- Enblad, Gunilla (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Amini, Rose-Marie (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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(creator_code:org_t)
- 2019-12-20
- 2020
- Engelska.
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Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 104:3, s. 207-213
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The prognostic value of site of nodal involvement in diffuse large B-cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single-centre study.METHODS: Contrast-enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node.RESULTS: Patients with abdominal nodal disease had inferior lymphoma-specific survival (P = .04) and presented with higher age-adjusted IPI (P < .001), lactate dehydrogenase (P < .001) and more often advanced stage (P < .001), bulky disease (P < .001), B symptoms (P < .001), and double expression of MYC and BCL2 (P = .02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (P < .02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy.CONCLUSION: Diffuse large B-cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- BCL2
- DLBCL
- MYC
- abdominal lymph node
- survival
- Patologi
- Pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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