Sökning: onr:"swepub:oai:DiVA.org:uu-401230" > ALCAM predicts futu...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04018naa a2200505 4500 | |
001 | oai:DiVA.org:uu-401230 | |
003 | SwePub | |
008 | 200107s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4012302 URI |
024 | 7 | a https://doi.org/10.1016/j.atherosclerosis.2019.11.0312 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ueland, Thor4 aut |
245 | 1 0 | a ALCAM predicts future cardiovascular death in acute coronary syndromes :b Insights from the PLATO trial |
264 | 1 | b Elsevier,c 2020 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND AND AIMS: Activated leukocyte cell adhesion molecule (ALCAM) is upregulated during inflammation and involved in transmigration of leukocytes and T-cell activation. We hypothesized that ALCAM might be associated with recurrent events in patients with acute coronary syndromes (ACS).METHODS: ALCAM was measured in serum obtained on admission, at discharge, 1 month and 6 months in a subgroup of 5165 patients admitted with ACS and included in the PLATelet inhibition and patient Outcomes (PLATO) trial (NCT00391872). The association between ALCAM and the composite endpoint and its components, including cardiovascular (CV) death, non-procedural spontaneous myocardial infarction (MI) or stroke during 1-year follow-up, was assessed by Cox proportional hazards models with incremental addition of clinical risk factors and biomarkers (including high-sensitivity troponin T, N-terminal pro-B-type natriuretic peptide and growth differentiation factor-15).RESULTS: The median (Q1-Q3) concentration of ALCAM at admission was 97 (80-116) ng/mL. A 50% higher level of ALCAM on admission was associated with a hazard ratio (HR) of 1.16 (95% confidence interval [1.00-1.34] p = 0.043) for the composite endpoint in fully adjusted analysis, mainly driven by the association with CV death (HR 1.45 [1.16-1.82] p = 0.0012).CONCLUSIONS: In patients with ACS, admission level of ALCAM was independently associated with adverse outcome including CV death even after adjustment for established inflammatory and cardiac biomarkers. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Activated leukocyte cell adhesion molecule | |
653 | a Acute coronary syndromes | |
653 | a CV death | |
653 | a Prognosis | |
700 | 1 | a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,kardiologi4 aut0 (Swepub:uu)axeak985 |
700 | 1 | a Ghukasyan, Tateviku Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),UCR4 aut0 (Swepub:uu)tatgh570 |
700 | 1 | a Michelsen, Annika E4 aut |
700 | 1 | a Becker, Richard C4 aut |
700 | 1 | a Bertilsson, Maria4 aut |
700 | 1 | a Budaj, Andrzej4 aut |
700 | 1 | a Cornel, Jan H4 aut |
700 | 1 | a Himmelmann, Anders4 aut |
700 | 1 | a James, Stefan,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367 |
700 | 1 | a Siegbahn, Agneta,d 1947-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi,UCR4 aut0 (Swepub:uu)agsie424 |
700 | 1 | a Storey, Robert F4 aut |
700 | 1 | a Kontny, Frederic4 aut |
700 | 1 | a Aukrust, Pål4 aut |
700 | 1 | a Wallentin, Lars,d 1943-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR4 aut0 (Swepub:uu)larswall |
710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Atherosclerosisd : Elsevierg 293, s. 35-41q 293<35-41x 0021-9150x 1879-1484 |
856 | 4 | u https://munin.uit.no/bitstream/10037/19916/2/article.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401230 |
856 | 4 8 | u https://doi.org/10.1016/j.atherosclerosis.2019.11.031 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.