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Sökning: onr:"swepub:oai:DiVA.org:uu-401230" > ALCAM predicts futu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004018naa a2200505 4500
001oai:DiVA.org:uu-401230
003SwePub
008200107s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4012302 URI
0247 a https://doi.org/10.1016/j.atherosclerosis.2019.11.0312 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ueland, Thor4 aut
2451 0a ALCAM predicts future cardiovascular death in acute coronary syndromes :b Insights from the PLATO trial
264 1b Elsevier,c 2020
338 a print2 rdacarrier
520 a BACKGROUND AND AIMS: Activated leukocyte cell adhesion molecule (ALCAM) is upregulated during inflammation and involved in transmigration of leukocytes and T-cell activation. We hypothesized that ALCAM might be associated with recurrent events in patients with acute coronary syndromes (ACS).METHODS: ALCAM was measured in serum obtained on admission, at discharge, 1 month and 6 months in a subgroup of 5165 patients admitted with ACS and included in the PLATelet inhibition and patient Outcomes (PLATO) trial (NCT00391872). The association between ALCAM and the composite endpoint and its components, including cardiovascular (CV) death, non-procedural spontaneous myocardial infarction (MI) or stroke during 1-year follow-up, was assessed by Cox proportional hazards models with incremental addition of clinical risk factors and biomarkers (including high-sensitivity troponin T, N-terminal pro-B-type natriuretic peptide and growth differentiation factor-15).RESULTS: The median (Q1-Q3) concentration of ALCAM at admission was 97 (80-116) ng/mL. A 50% higher level of ALCAM on admission was associated with a hazard ratio (HR) of 1.16 (95% confidence interval [1.00-1.34] p = 0.043) for the composite endpoint in fully adjusted analysis, mainly driven by the association with CV death (HR 1.45 [1.16-1.82] p = 0.0012).CONCLUSIONS: In patients with ACS, admission level of ALCAM was independently associated with adverse outcome including CV death even after adjustment for established inflammatory and cardiac biomarkers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Activated leukocyte cell adhesion molecule
653 a Acute coronary syndromes
653 a CV death
653 a Prognosis
7001 a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,kardiologi4 aut0 (Swepub:uu)axeak985
7001 a Ghukasyan, Tateviku Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),UCR4 aut0 (Swepub:uu)tatgh570
7001 a Michelsen, Annika E4 aut
7001 a Becker, Richard C4 aut
7001 a Bertilsson, Maria4 aut
7001 a Budaj, Andrzej4 aut
7001 a Cornel, Jan H4 aut
7001 a Himmelmann, Anders4 aut
7001 a James, Stefan,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367
7001 a Siegbahn, Agneta,d 1947-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi,UCR4 aut0 (Swepub:uu)agsie424
7001 a Storey, Robert F4 aut
7001 a Kontny, Frederic4 aut
7001 a Aukrust, Pål4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR4 aut0 (Swepub:uu)larswall
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Atherosclerosisd : Elsevierg 293, s. 35-41q 293<35-41x 0021-9150x 1879-1484
8564 u https://munin.uit.no/bitstream/10037/19916/2/article.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401230
8564 8u https://doi.org/10.1016/j.atherosclerosis.2019.11.031

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