Sökning: onr:"swepub:oai:DiVA.org:uu-401723" > Metastatic colorect...
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000 | 04732naa a2200433 4500 | |
001 | oai:DiVA.org:uu-401723 | |
003 | SwePub | |
008 | 200108s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4017232 URI |
024 | 7 | a https://doi.org/10.1080/0284186X.2019.16912582 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mezheyeuski, Arturu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)artme913 |
245 | 1 0 | a Metastatic colorectal carcinomas with high SATB2 expression are associated with better prognosis and response to chemotherapy :b a population-based Scandinavian study |
264 | 1 | b Taylor & Francis,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Background: Survival and response to therapy in patients with metastatic colorectal cancer (mCRC) are very heterogeneous. There is an unmet need for better markers of prognosis and treatment benefit for mCRC patients. The homeobox 2 gene SATB2 has a highly specific expression in colorectal tissue and is associated with better prognosis in non-metastatic CRC.Material and methods: A population-based cohort of 798 mCRC patients was analysed. From primary tumour material, protein expression was assessed by immunohistochemistry. BRAF and KRAS mutation status was also determined. Associations with clinicopathological data, overall and progression-free survival and response to first-line chemotherapy were analysed.Results: Tumour tissue and clinical data were available from 467 patients. SATB2 was strongly expressed in 58% of cases, significantly more in left-sided, low-grade and wild-type BRAF tumours. Patients with high SATB2 tumours had longer overall survival compared with low SATB2 tumours (median 13 vs 8 months respectively, p < .001). Chemotherapy was given to 282 patients (63%). Patients with high SATB2 tumours had longer OS (median 22 vs 15 months respectively, p = .001) and more often responded to chemotherapy than those with low SATB2 (objective response 43% vs 29%, p = .02; clinical response 83% vs 67%, p = .004). Progression-free survival on first-line irinotecan chemotherapy was longer in high SATB2 cases (median 8 vs 4 months respectively, p = .019). Patients with both low SATB2 expression and mutated BRAF (n = 69) had particularly poor survival compared to the rest (median 8 and 12 months respectively, p = .001). In multivariable analysis, the SATB2 findings were independent of known clinicopathological prognostic markers, including BRAF mutation status.Conclusion: Patients with mCRC expressing high level of SATB2 have better prognosis and response to chemotherapy than those with low SATB2 expression. Patients with both low SATB2 expression and mutated BRAF had particularly poor prognosis and could thus benefit from more aggressive therapies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Pontén, Fredriku Uppsala universitet,Institutionen för immunologi, genetik och patologi,Fredrik Pontén4 aut0 (Swepub:uu)fredpont |
700 | 1 | a Edqvist, Per-Henrik Du Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)peedq227 |
700 | 1 | a Sundström, Magnusu Uppsala universitet,Institutionen för immunologi, genetik och patologi,Johan Botling4 aut0 (Swepub:uu)magnsund |
700 | 1 | a Thunberg, Ulfu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)ulfthunb |
700 | 1 | a Qvortrup, Camilla4 aut |
700 | 1 | a Pfeiffer, Per4 aut |
700 | 1 | a Sorbye, Halfdan4 aut |
700 | 1 | a Glimelius, Bengtu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)bengglim |
700 | 1 | a Dragomir, Ancau Uppsala universitet,Institutionen för immunologi, genetik och patologi,Fredrik Pontén4 aut0 (Swepub:uu)ancadrag |
710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t Acta Oncologicad : Taylor & Francisg 59:3, s. 284-290q 59:3<284-290x 0284-186Xx 1651-226X |
856 | 4 | u https://doi.org/10.1080/0284186X.2019.1691258y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1383785/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401723 |
856 | 4 8 | u https://doi.org/10.1080/0284186X.2019.1691258 |
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