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Nanowired delivery ...
Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
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- Sharma, Hari Shanker (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Muresanu, Dafin F. (författare)
- Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania
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- Castellani, Rudy J. (författare)
- Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA
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- Nozari, Ala (författare)
- Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA
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- Vicente Lafuente, Jose (författare)
- Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Spain
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- Tian, Z. Ryan (författare)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA
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- Ozkizilcik, Asya (författare)
- Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA
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- Manzhulo, Igor (författare)
- Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok, Russia;Far Eastern Fed Univ, Sch Biomed, Vladivostok, Russia
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- Moessler, Herbert (författare)
- Ever NeuroPharma, Oberburgau, Austria
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- Sharma, Aruna (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019
- 2019
- Engelska.
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Ingår i: NANONEUROPROTECTION AND NANONEUROTOXICOLOGY. - : ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD. - 9780444642080 ; , s. 145-200
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018-19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- Neurotrophic factors
- Cerebrolysin
- Antibodies
- Phosphorylated Tau protein
- Brain pathology
- Blood-brain barrier
- Brain edema
- Nanowired delivery
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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