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Rifampicin can be g...
Rifampicin can be given as flat-dosing instead of weight-band dosing
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- Susanto, Budi Octasari (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Svensson, Robin J. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Svensson, Elin M., 1985- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center , Nijmegen, The Netherlands
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- Aarnoutse, Rob (författare)
- Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center , Nijmegen, The Netherlands
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- Boeree, Martin J (författare)
- Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center , Nijmegen, The Netherlands
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- Simonsson, Ulrika S. H., Professor (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- 2019-12-23
- 2020
- Engelska.
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1058-4838 .- 1537-6591. ; 71:12, s. 3055-3060
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The weight-band dosing in tuberculosis treatment regimen has been implemented in clinical practice for decades. Patients will receive different number of fixed dose combination (FDC) tablets according to their weight-band. However, some analysis have shown that weight was not the best covariate to explain variability of rifampicin exposure. Furthermore, the rationale for using weight-band dosing instead of flat-dosing becomes questionable. Therefore, this study aimed to compare the average and the variability of rifampicin exposure after weight-band dosing and flat-dosing.METHODS: Rifampicin exposure were simulated using previously published population pharmacokinetics model at dose 10-40 mg/kg for weight-band dosing and dose 600-2400 mg for flat-dosing. The median AUC0-24h after day 7 and 14 were compared as well as the variability of each dose group between weight-band and flat-dosing.RESULTS: The difference of median AUC0-24h of all dose groups between flat-dosing and weight-band dosing were considered low (< 20%) except for the lowest dose. At the dose of 10 mg/kg (600 mg for flat-dosing), flat-dosing resulted in higher median AUC0-24h compared to the weight-band dosing. A marginal decrease in between-patient variability was predicted for weight-band dosing compared to flat-dosing.CONCLUSIONS: Weight-band dosing yields a small and non-clinically relevant decrease in variability of AUC0-24h.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- flat-dosing
- pharmacokinetics
- rifampicin
- simulation
- weight-band dosing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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