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Sökning: onr:"swepub:oai:DiVA.org:uu-403856" > Cardiac left ventri...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004491naa a2200517 4500
001oai:DiVA.org:uu-403856
003SwePub
008200205s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144017366
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4038562 URI
0247 a https://doi.org/10.1016/j.schres.2019.12.0422 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1440173662 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Andreou, Dimitriosu Karolinska Institutet4 aut
2451 0a Cardiac left ventricular ejection fraction in men and women with schizophrenia on long-term antipsychotic treatment
264 1b Elsevier BV,c 2020
338 a electronic2 rdacarrier
520 a Patients with schizophrenia exhibit a higher cardiovascular mortality compared to the general population which has been attributed to life-style factors, genetic susceptibility and antipsychotic medication. Recent echocardiographic studies have pointed to an association between clozapine treatment and reduced left ventricular ejection fraction (LVEF), a measure that has been inversely associated with adverse outcomes including all-cause mortality. Cardiovascular magnetic resonance (CMR) is considered the reference method for LVEF measurement. The aim of the present study was to investigate the LVEF in patients with schizophrenia on long-term treatment with antipsychotics and healthy controls. Twenty-nine adult patients with schizophrenia on long-term medication with antipsychotics and 27 age-, sex- and body mass index-matched healthy controls (mean ages 44 and 45 years, respectively) were recruited from outpatient psychiatric clinics in Uppsala, Sweden. The participants were interviewed and underwent physical examination, biochemical analyses, electrocardiogram and CMR. Men with schizophrenia on long-term antipsychotic treatment showed significantly lower LVEF than controls (p = 0.0076), whereas no such difference was evident among women (p = 0.44). Specifically, clozapine-treated male patients had 10.6% lower LVEF than male controls (p = 0.0064), whereas the LVEF was 5.5% below that of controls among male patients treated with non-clozapine antipsychotics (p = 0.047). Among medicated men with schizophrenia, we found significantly lower LVEF compared to healthy individuals, suggesting the need of routine cardiac monitoring in this patient group. This is the first study showing a significant negative association between treatment with non-clozapine antipsychotics and LVEF.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Antipsychotics
653 a Cardiovascular magnetic resonance
653 a Clozapine
653 a Left ventricular ejection fraction
653 a Schizophrenia
7001 a Saetre, Peter4 aut
7001 a Milesson Fors, Björnu Uppsala universitet,Ekselius: Psykiatri4 aut0 (Swepub:uu)bjormile
7001 a Nilsson, Björn Mikaelu Uppsala universitet,Ekselius: Psykiatri4 aut0 (Swepub:uu)bjornilss
7001 a Kullberg, Joel,d 1979-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jokul377
7001 a Jönsson, Erik Gunnaru Karolinska Institutet4 aut
7001 a Ebeling Barbier, Charlotteu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)chebe226
7001 a Agartz, Ingridu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Ekselius: Psykiatri4 org
7730 t Schizophrenia Researchd : Elsevier BVg 218, s. 226-232q 218<226-232x 0920-9964x 1573-2509
8564 u https://doi.org/10.1016/j.schres.2019.12.042y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1391707/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.schres.2019.12.042
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403856
8564 8u https://doi.org/10.1016/j.schres.2019.12.042
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144017366

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