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Bipolar disorder dy...
Bipolar disorder dynamics : affective instabilities, relaxation oscillations and noise
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- Bonsall, Michael B. (författare)
- Univ Oxford, Dept Zool, Oxford OX1 3PS, England;St Peters Coll, Oxford OX1 2DL, England
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- Geddes, John R. (författare)
- Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX1 7JX, England
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- Goodwin, Guy M. (författare)
- Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX1 7JX, England
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- Holmes, Emily A. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-11-06
- 2015
- Engelska.
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Ingår i: Journal of the Royal Society Interface. - : ROYAL SOC. - 1742-5689 .- 1742-5662. ; 12:112
- Relaterad länk:
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https://royalsociety...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Bipolar disorder is a chronic, recurrent mental illness characterized by extreme episodes of depressed and manic mood, interspersed with less severe but highly variable mood fluctuations. Here, we develop a novel mathematical approach for exploring the dynamics of bipolar disorder. We investigate how the dynamics of subjective experience of mood in bipolar disorder can be understood using a relaxation oscillator (RO) framework and test the model against mood time-series fluctuations from a set of individuals with bipolar disorder. We show that variable mood fluctuations in individuals diagnosed with bipolar disorder can be driven by the coupled effects of deterministic dynamics (captured by ROs) and noise. Using a statistical likelihood-based approach, we show that, in general, mood dynamics are described by two independent ROs with differing levels of endogenous variability among individuals. We suggest that this sort of nonlinear approach to bipolar disorder has neurobiological, cognitive and clinical implications for understanding this mental illness through a mechacognitive framework.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- likelihood
- mechacognition
- mood variability
- mood dynamics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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