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The plasma protein ...
The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : A meta-analysis and a longitudinal evaluation
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- Lind, Lars (författare)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Gigante, Bruna (författare)
- Karolinska Institutet,Karolinska Institute
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- Borne, Yan (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Mälarstig, Anders (författare)
- Karolinska Institutet,Karolinska Institute
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia,University of New South Wales
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Karolinska Institutet,Karolinska Institute,Dalarna University College,Medicinsk vetenskap
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- Ingelsson, Erik (författare)
- Stanford Univ, Stanford Diabet Res Ctr, Stanford Cardiovasc Inst, Dept Med,Div Cardiovasc Med, Stanford, CA 94305 USA,Stanford University
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- Baldassarre, Damiano (författare)
- Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy;IRCCS, Ctr Cardiol Monzino, Milan, Italy,University of Milan,Centro Cardiologico Monzino
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- Tremoli, Elena (författare)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy,Centro Cardiologico Monzino
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- Veglia, Fabrizio (författare)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy,Centro Cardiologico Monzino
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- Hamsten, Anders (författare)
- Karolinska Institutet,Karolinska Institute
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Nilsson, Jan (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2020
- 2020
- Engelska.
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Ingår i: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 295, s. 25-30
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease.Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline, and 86 cardiovascular-related proteins were analyzed. In the PIVUS study only, IMT-CCA and IMT-bulb were investigated in relation to incident atherosclerotic disease over 10 years of follow-up.Results: In a meta-analysis of the analysis performed separately in the cohorts, three proteins, matrix metalloproteinase-12 (MMP-12), hepatocyte growth factor (HGF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), were associated with IMT-CCA when adjusted for traditional cardiovascular risk factors. Five proteins were associated with IMT-bulb (MMP-12, growth/differentiation factor 15 (GDF-15), osteoprotegerin, growth hormone and renin). Following adjustment for cardiovascular risk factors, IMT-bulb was significantly more closely related to incident stroke or myocardial infarction (total number of cases, 111) than IMT-CCA in the PIVUS study (HR 1.51 for 1 SD, 95%CI 1.21-1.87, p < 0.001 vs HR 1.17, 95%CI 0.93-1.47, p = 0.16). MMP-12 levels were related to this combined end-point (HR 1.30, 95%CI 1.08-1.56, p = 0.0061).Conclusions: Elevated levels of MMP-12 were associated with both IMT-CCA and IMT-bulb, but other proteins were significantly related to IMT in only one of these locations. The finding that IMT-bulb was more closely related to incident atherosclerotic disease than IMT-CCA emphasizes a difference between these measurements of IMT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Atherosclerosis
- Proteomics
- Carotid artery
- Meta-analysis
- Ultrasound
- Atherosclerosis
- Carotid artery
- Meta-analysis
- Proteomics
- Ultrasound
- Hälsa och välfärd
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Lind, Lars
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Gigante, Bruna
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Borne, Yan
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Mälarstig, Ander ...
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Sundström, Johan ...
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Ärnlöv, Johan, 1 ...
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Ingelsson, Erik
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Baldassarre, Dam ...
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Tremoli, Elena
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Veglia, Fabrizio
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Hamsten, Anders
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Orho-Melander, M ...
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Nilsson, Jan
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Melander, Olle
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Engström, Gunnar
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet
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Högskolan Dalarna