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Blood transcriptome...
Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks
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- Maruyama, Sandra R. (författare)
- Univ Sao Paulo, Ribeirao Preto Sch Med, Ribeirao Preto, SP, Brazil;Univ Fed Sao Carlos, Ctr Biol Sci & Hlth, Dept Genet & Evolut, Sao Carlos, SP, Brazil
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- Carvalho, Benilton (författare)
- Univ Estadual Campinas, Campinas, SP, Brazil
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- Gonzalez-Porta, Mar (författare)
- EMBL EBI, Hinxton, England;Illumina Ctr, Cambridge, England
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- Rung, Johan (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,EMBL EBI, Hinxton, England
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- Brazma, Alvis (författare)
- EMBL EBI, Hinxton, England
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- Gardinassi, Luiz Gustavo (författare)
- Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP, Brazil
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- Ferreira, Beatriz R. (författare)
- Univ Sao Paulo, Ribeirao Preto Sch Nursing, Ribeirao Preto, SP, Brazil
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- Banin, Tamy M. (författare)
- Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP, Brazil
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- Verissimo, Cecilia J. (författare)
- Sao Paulo Inst Anim Sci IZ, Nova Odessa, SP, Brazil
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- Katiki, Luciana M. (författare)
- Sao Paulo Inst Anim Sci IZ, Nova Odessa, SP, Brazil
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- de Miranda-Santos, Isabel K. F. (författare)
- Univ Sao Paulo, Ribeirao Preto Sch Med, Ribeirao Preto, SP, Brazil
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(creator_code:org_t)
- 2019-12-18
- 2019
- Engelska.
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Ingår i: NPJ VACCINES. - : NATURE PUBLISHING GROUP. - 2059-0105. ; 4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ticks cause massive damage to livestock and vaccines are one sustainable alternative for the acaricide poisons currently heavily used to control infestations. An experimental vaccine adjuvanted with alum and composed by four recombinant salivary antigens mined with reverse vaccinology from a transcriptome of salivary glands from Rhipicephalus microplus ticks was previously shown to present an overall efficacy of 73.2% and cause a significant decrease of tick loads in artificially tick-infested, immunized heifers; this decrease was accompanied by increased levels of antigen-specific IgG1 and IgG2 antibodies, which were boosted during a challenge infestation. In order to gain insights into the systemic effects induced by the vaccine and by the tick challenge we now report the gene expression profile of these hosts' whole-blood leukocytes with RNA-seq followed by functional analyses. These analyses show that vaccination induced unique responses to infestations; genes upregulated in the comparisons were enriched for processes associated with chemotaxis, cell adhesion, T-cell responses and wound repair. Blood transcriptional modules were enriched for activation of dendritic cells, cell cycle, phosphatidylinositol signaling, and platelets. Together, the results indicate that by neutralizing the tick's salivary mediators of parasitism with vaccine-induced antibodies, the bovine host is able to mount normal homeostatic responses that hinder tick attachment and haematophagy and that the tick otherwise suppresses with its saliva.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Maruyama, Sandra ...
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Carvalho, Benilt ...
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Gonzalez-Porta, ...
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Rung, Johan
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Brazma, Alvis
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Gardinassi, Luiz ...
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visa fler...
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Ferreira, Beatri ...
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Banin, Tamy M.
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Verissimo, Cecil ...
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Katiki, Luciana ...
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de Miranda-Santo ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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NPJ VACCINES
- Av lärosätet
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Uppsala universitet