Sökning: onr:"swepub:oai:DiVA.org:uu-407978" > The Risk of Ovarian...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 10305naa a2200985 4500 | |
001 | oai:DiVA.org:uu-407978 | |
003 | SwePub | |
008 | 200403s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-169125 | |
009 | oai:prod.swepub.kib.ki.se:143127158 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4079782 URI |
024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-19-28502 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1691252 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1431271582 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Trabert, Brittonu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut |
245 | 1 0 | a The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles :b An Analysis from the Ovarian Cancer Cohort Consortium (OC3) |
264 | 1 | b AMER ASSOC CANCER RESEARCH,c 2020 |
338 | a print2 rdacarrier | |
520 | a Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Tworoger, Shelley S.u H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 aut |
700 | 1 | a O'Brien, Katie M.u NIEHS, Epidemiol Branch, NIH, Durham, NC USA4 aut |
700 | 1 | a Townsend, Mary K.u H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 aut |
700 | 1 | a Fortner, Renee T.u German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany4 aut |
700 | 1 | a Iversen, Edwin S.u Duke Univ, Dept Stat Sci, Durham, NC USA4 aut |
700 | 1 | a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut |
700 | 1 | a White, Emilyu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA4 aut |
700 | 1 | a Amiano, Pilaru BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain;CIBER Epidemiol & Salud Publ, Madrid, Spain4 aut |
700 | 1 | a Arslan, Alan A.u NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA,Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada,Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut |
700 | 1 | a Bernstein, Leslieu City Hope Natl Med Ctr, Duarte, CA USA4 aut |
700 | 1 | a Brinton, Louise A.u NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut |
700 | 1 | a Buring, Julie E.u Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA4 aut |
700 | 1 | a Dossus, Laureu IARC, Lyon, France4 aut |
700 | 1 | a Fraser, Gary E.u Loma Linda Univ, Loma Linda, CA 92350 USA4 aut |
700 | 1 | a Gaudet, Mia M.u Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA4 aut |
700 | 1 | a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia4 aut |
700 | 1 | a Gram, Inger T.u Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway4 aut |
700 | 1 | a Harris, Holly R.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA4 aut |
700 | 1 | a Bolton, Judith Hoffmanu Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA;Johns Hopkins Sch Med, Baltimore, MD USA4 aut |
700 | 1 | a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi,Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Jones, Michael E.u Inst Canc Res, Div Genet & Epidemiol, London, England4 aut |
700 | 1 | a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany4 aut |
700 | 1 | a Kirsh, Victoria A.u Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada4 aut |
700 | 1 | a Knutsen, Synnove F.u Loma Linda Univ, Loma Linda, CA 92350 USA4 aut |
700 | 1 | a Kvaskoff, Marinau Univ Paris Saclay, Univ Paris Sud, UVSQ, INSERM,Fac Med,CESP, Villejuif, France;Gustave Roussy, Villejuif, France4 aut |
700 | 1 | a Lacey, James, Vu City Hope Natl Med Ctr, Duarte, CA USA4 aut |
700 | 1 | a Lee, I-Minu Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA4 aut |
700 | 1 | a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia4 aut |
700 | 1 | a Onland-Moret, N. Charlotteu Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands4 aut |
700 | 1 | a Overvad, Kimu Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark4 aut |
700 | 1 | a Patel, Alpa, Vu Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA4 aut |
700 | 1 | a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA4 aut |
700 | 1 | a Poynter, Jenny N.u Univ Minnesota, Div Pediat Epidemiol & Clin Res, Minneapolis, MN USA4 aut |
700 | 1 | a Riboli, Eliou Imperial Coll London, Sch Publ Hlth, London, England4 aut |
700 | 1 | a Robien, Kimu George Washington Univ, Milken Inst Sch Publ Hlth, Dept Exercise & Nutr Sci, Washington, DC USA4 aut |
700 | 1 | a Rohan, Thomas E.u Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA4 aut |
700 | 1 | a Sandler, Dale P.u NIEHS, Epidemiol Branch, NIH, Durham, NC USA4 aut |
700 | 1 | a Schairer, Catherineu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut |
700 | 1 | a Schouten, Leo J.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut |
700 | 1 | a Setiawan, Veronica W.u Univ Southern Calif, Los Angeles, CA 90007 USA4 aut |
700 | 1 | a Swerdlow, Anthony J.u Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England4 aut |
700 | 1 | a Travis, Ruth C.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England4 aut |
700 | 1 | a Trichopoulou, Antoniau Hellen Hlth Fdn, Athens, Greece4 aut |
700 | 1 | a van den Brandt, Piet A.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut |
700 | 1 | a Visvanathan, Kalau Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway4 aut |
700 | 1 | a Wilkens, Lynne R.u Univ Hawaii, Populat Sci Pacific Program Canc Epidemiol, Canc Ctr, Honolulu, HI 96822 USA4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut0 (Swepub:uu)alwol516 |
700 | 1 | a Zeleniuch-Jacquotte, Anneu NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA4 aut |
700 | 1 | a Wentzensen, Nicolasu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut |
710 | 2 | a NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USAb H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 org |
773 | 0 | t Cancer Researchd : AMER ASSOC CANCER RESEARCHg 80:5, s. 1210-1218q 80:5<1210-1218x 0008-5472x 1538-7445 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407978 |
856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-19-2850 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169125 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143127158 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy