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Exposure to risperi...
Exposure to risperidone versus other antipsychotics and risk of osteoporosis-related fractures : a population-based study
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- Clapham, Eric (författare)
- Uppsala universitet,Ekselius: Psykiatri,Karolinska Univ Hosp, Ctr Pharmacoepidemiol CPE, Karolinska Inst, Dept Med Solna, Solna, Sweden
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- Bodén, Robert, 1973- (författare)
- Uppsala universitet,Ekselius: Psykiatri,Karolinska Univ Hosp, Ctr Pharmacoepidemiol CPE, Karolinska Inst, Dept Med Solna, Solna, Sweden
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- Reutfors, J. (författare)
- Karolinska Institutet
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- Svensson, T. (författare)
- Karolinska Univ Hosp, Ctr Pharmacoepidemiol CPE, Karolinska Inst, Dept Med Solna, Solna, Sweden
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- Ramcharran, D. (författare)
- Janssen Global Res & Dev Epidemiol, Titusville, NJ USA
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- Qiu, H. (författare)
- Janssen Global Res & Dev Epidemiol, Titusville, NJ USA
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- Kileer, H. (författare)
- Karolinska Univ Hosp, Ctr Pharmacoepidemiol CPE, Karolinska Inst, Dept Med Solna, Solna, Sweden
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- Bahmanyar, S. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-10-11
- 2020
- Engelska.
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Ingår i: Acta Psychiatrica Scandinavica. - : WILEY. - 0001-690X .- 1600-0447. ; 141:1, s. 74-83
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Abstract
Ämnesord
Stäng
- Objective Antipsychotics may increase serum prolactin, which has particularly been observed with risperidone. Further, hyperprolactinemia has been linked to osteoporosis-related fractures. Therefore, we investigated fracture risk in a nationwide cohort exposed to antipsychotics. Methods Swedish registers were used to identify adults with two consecutive dispensations of risperidone (n = 38 211), other atypical antipsychotics not including paliperidone (n = 60 691), or typical antipsychotics (n = 17 445) within three months between 2006 and 2013. An osteoporosis-related fracture was defined as a non-open hip/femur fracture in primary analyses. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results Risperidone users were on average older (mean age of 68, 44, and 63 years for risperidone, other atypical antipsychotics, and typical antipsychotics respectively). Compared with other atypical antipsychotics, there was no association between risperidone and osteoporosis-related fractures in the overall (HR = 1.04, CI: 0.91-1.19) or age-stratified analyses. A significantly increased risk of typical antipsychotics (HR = 1.24, CI: 1.07-1.45) compared with other atypical antipsychotics remained for ages >45 years. Conclusion Risperidone does not appear to be associated with an increased risk of osteoporosis-related fracture compared with other atypical antipsychotic agents as a group. For typical antipsychotics, a moderately elevated risk of hip fractures was noted compared with other atypical antipsychotics, possibly because of residual confounding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- risperidone
- atypical antipsychotics
- osteoporosis
- fracture
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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