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Stepwise mass scree...
Stepwise mass screening for atrial fibrillation using N-terminal B-type natriuretic peptide : the STROKESTOP II study
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- Gudmundsdottir, Katrin Kemp (författare)
- Karolinska Institutet
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- Fredriksson, Tove (författare)
- Karolinska Institutet
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- Svennberg, Emma (författare)
- Karolinska Institutet
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- Al-Khalili, Faris (författare)
- Karolinska Institutet
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- Friberg, Leif (författare)
- Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, Div Cardiovasc Med, SE-18288 Stockholm, Sweden
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- Frykman, Viveka (författare)
- Karolinska Institutet
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- Hijazi, Ziad (författare)
- Uppsala universitet,Kardiologi
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- Rosenqvist, Mårten (författare)
- Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, Div Cardiovasc Med, SE-18288 Stockholm, Sweden
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- Engdahl, Johan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-09-17
- 2020
- Engelska.
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Ingår i: Europace. - : OXFORD UNIV PRESS. - 1099-5129 .- 1532-2092. ; 22:1, s. 24-32
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Aims: To study the prevalence of unknown atrial fibrillation (AF) in a high-risk, 75/76-year-old, population using N-terminal B-type natriuretic peptide (NT-proBNP) and handheld electrocardiogram (ECG) recordings in a stepwise screening procedure.Methods and results: The STROKESTOP II study is a population-based cohort study in which all 75/76-year-old in the Stockholm region (n = 28 712) were randomized 1:1 to be invited to an AF screening programme or to serve as the control group. Participants without known AF had NT-proBNP analysed and were stratified into low-risk (NT-proBNP <125 ng/L) and high-risk (NT-proBNP >= 125 ng/L) groups. The high-risk group was offered extended ECG-screening, whereas the low-risk group performed only one single-lead ECG recording. In total, 6868 individuals accepted the screening invitation of which 6315 (91.9%) did not have previously known AF. New AF was detected in 2.6% [95% confidence interval (CI) 2.2-3.0] of all participants without previous AF. In the high-risk group (n = 3766/6315, 59.6%), AF was diagnosed in 4.4% (95% CI 3.7-5.1) of the participants. Out of these, 18% had AF on their index-ECG. In the low-risk group, one participant was diagnosed with AF on index-ECG. The screening procedure resulted in an increase in known prevalence from 8.1% to 10.5% among participants. Oral anticoagulant treatment was initiated in 94.5% of the participants with newly diagnosed AF.Conclusion: N-terminal B-type natriuretic peptide-stratified systematic screening for AF identified 4.4% of the high-risk participants with new AF. Oral anticoagulant treatment initiation was well accepted in the group diagnosed with new AF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atrial fibrillation
- N-terminal B-type natriuretic peptide
- Screening
- Stroke
- Oral anticoagulants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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