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Mass Cytometry Stud...
Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
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- Magnusson, Louise (författare)
- Linköpings universitet,Uppsala universitet,Transplantation och regenerativ medicin,Linkoping Univ, Dept Biomed & Clin Sci, Div Children & Women Hlth, Linkoping, Sweden.,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Uppsala Univ, Sweden
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- Barcenilla, Hugo (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Pihl, Mikael (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Bensing, Sophie (författare)
- Karolinska Institutet
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- Espes, Daniel, 1985- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Casas, Rosaura (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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(creator_code:org_t)
- 2020-02-21
- 2020
- Engelska.
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Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 11
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Although there is evidence that autoimmune diseases share similar immunogenetic mechanisms, studies comparing peripheral CD45(+) cells from patients with autoimmune endocrine diseases in parallel are limited. In this study, we applied high-dimensional single-cell mass cytometry to phenotypically characterize PBMC from patients with new-onset (N-T1D) and long-standing type 1 diabetes, Hashimoto's thyroiditis (HT), Graves' disease and autoimmune Addison's disease (AD), as well as healthy controls. The frequency of CD20(lo)CD27(hi)CD38(hi)HLA-DRint plasmablasts, CD86(+)CD14(lo)CD16(+) non-classical monocytes and two subsets of CD56(dim)HLA-DR+IFN-gamma(+) NK cells were increased in patients with HT. Subsets of CD56(dim)CD69(+)HLA-DR- NK cells and CD8(+) TEMRA cells, both expressing IFN-gamma, were expanded and reduced, respectively, in the N-T1D group. In addition, patients with AD were characterized by an increased percentage of central memory CD8(+) T cells that expressed CCR4, GATA3, and IL-2. We demonstrate that patients with N-T1D, HT, and AD had altered frequencies of distinct subsets within antigen-presenting and cytotoxic cell lineages. Previously unreported alterations of specific cell subsets were identified in samples from patients with HT and AD. Our study might contribute to a better understanding of shared and diverging immunological features between autoimmune endocrine diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- mass cytometry (CyTOF)
- type 1 diabetes
- Hashimoto's thyroiditis
- Graves' disease
- Addison's disease
- antigen-presenting cells
- NK cells
- T cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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