Sökning: onr:"swepub:oai:DiVA.org:uu-409967" > T-cell acute lympho...
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000 | 05972naa a2200673 4500 | |
001 | oai:DiVA.org:uu-409967 | |
003 | SwePub | |
008 | 200505s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-169891 | |
009 | oai:prod.swepub.kib.ki.se:143347418 | |
009 | oai:gup.ub.gu.se/286616 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4099672 URI |
024 | 7 | a https://doi.org/10.1038/s41375-019-0598-22 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1698912 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1433474182 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2866162 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Quist-Paulsen, P.u Univ Trondheim Hosp, St Olavs Hosp, Dept Hematol, Trondheim, Norway.4 aut |
245 | 1 0 | a T-cell acute lymphoblastic leukemia in patients 1-45 years treated with the pediatric NOPHO ALL2008 protocol |
264 | c 2019-10-14 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
338 | a print2 rdacarrier | |
520 | a The NOPHO ALL2008 is a population-based study using an unmodified pediatric protocol in patients 1-45 years of age with acute lymphoblastic leukemia. Patients with T-ALL were given a traditional pediatric scheme if fast responding (minimal residual disease (MRD) < 0.1% day 29), or intensive block-based chemotherapy if slow responding (MRD > 0.1% day 29). Both treatment arms included pediatric doses of high-dose methotrexate and asparaginase. If MRD >= 5% on day 29 or >= 0.1% after consolidation, patients were assigned to allogeneic hematopoietic stem cell transplantation. The 5-year overall survival of the 278 T-ALL patients was 0.75 (95% CI 0.69-0.81), being 0.82 (0.74-0.88) for patients 1.0-9.9 years, 0.76 (0.66-0.86) for those 10.0-17.9 years, and 0.65 (0.55-0.75) for the older patients. The risk of death in first remission was significantly higher in adults (12%) compared with the 1-9 years group (4%). The MRD responses in the three age groups were similar, and only a nonsignificant increase in relapse risk was found in adults. In conclusion, an unmodified pediatric protocol in patients 1-45 years is effective in all age groups. The traditional pediatric treatment schedule was safe for all patients, but the intensive block therapy led to a high toxic death rate in adults. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
700 | 1 | a Toft, N.u Univ Copenhagen, Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.4 aut |
700 | 1 | a Heyman, M.u Karolinska Institutet4 aut |
700 | 1 | a Abrahamsson, Jonas,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xabrjo |
700 | 1 | a Griskevicius, L.u Vilnius Univ, Vilnius Univ Hosp Santaros Klinikos, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania.4 aut |
700 | 1 | a Hallböök, Heleneu Uppsala universitet,Hematologi4 aut0 (Swepub:uu)helehall |
700 | 1 | a Jonsson, O. G.u Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.4 aut |
700 | 1 | a Palk, K.u North Estonia Med Ctr, Dept Hematol, Tallinn, Estonia.4 aut |
700 | 1 | a Vaitkeviciene, G.u Vilnius Univ, Vilnius Univ Hosp Santariskiu Klinikos, Childrens Hosp, Ctr Pediat Oncol & Hematol, Vilnius, Lithuania.4 aut |
700 | 1 | a Vettenranta, K.u Helsinki Univ Cent Hosp, Hosp Children & Adolescents, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.4 aut |
700 | 1 | a Asberg, A.u Univ Trondheim Hosp, St Olavs Hosp, Dept Pediat, Trondheim, Norway.4 aut |
700 | 1 | a Frandsen, T. L.u Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.4 aut |
700 | 1 | a Opdahl, S.u NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway.4 aut |
700 | 1 | a Marquart, H. V.u Univ Hosp, Rigshosp, Dept Clin Immunol, Sect 7631, Copenhagen, Denmark.,Umea Univ, Dept Med Biosci Pathol, Umea, Sweden.4 aut |
700 | 1 | a Siitonen, S.u Helsinki Univ Cent Hosp, Dept Clin Chem, Helsinki, Finland.4 aut |
700 | 1 | a Osnes, L. T.u Oslo Univ Hosp, Dept Immunol, Oslo, Norway.4 aut |
700 | 1 | a Hultdin, Magnusu Umeå universitet,Patologi4 aut0 (Swepub:umu)magn0001 |
700 | 1 | a Overgaard, U. M.u Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark.4 aut |
700 | 1 | a Wartiovaara-Kautto, U.u Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Hematol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.4 aut |
700 | 1 | a Schmiegelow, K.u Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.4 aut |
710 | 2 | a Univ Trondheim Hosp, St Olavs Hosp, Dept Hematol, Trondheim, Norway.b Univ Copenhagen, Herlev Univ Hosp, Dept Hematol, Herlev, Denmark.4 org |
773 | 0 | t Leukemiad : Springer Science and Business Media LLCg 34:2, s. 347-357q 34:2<347-357x 0887-6924x 1476-5551 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409967 |
856 | 4 8 | u https://doi.org/10.1038/s41375-019-0598-2 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169891 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143347418 |
856 | 4 8 | u https://gup.ub.gu.se/publication/286616 |
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