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Early increment of ...
Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke
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- Kwon, Hyuk Sung (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Lee, Eun-Hye (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
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- Park, Hyun-Hee (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Jin, Jeong-Hwa (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Choi, Hojin (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Lee, Kyu-Yong (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Lee, Young Joo (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Lee, Jae-Hong (författare)
- Univ Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea.
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- de Oliveira, Felipe Marques Souza (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Kim, Hyun Young (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Kim, Young Seo (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Kim, Bum Joon (författare)
- Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Heo, Sung Hyuk (författare)
- Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Chang, Dae-Il (författare)
- Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
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- Kamali-Moghaddam, Masood (författare)
- Uppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab
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- Koh, Seong-Ho (författare)
- Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
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Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea. (creator_code:org_t)
- ELSEVIER SCI LTD, 2020
- 2020
- Engelska.
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Ingår i: Journal of clinical neuroscience. - : ELSEVIER SCI LTD. - 0967-5868 .- 1532-2653. ; 73, s. 215-218
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- sTREM2
- Microglia
- Ischemic stroke
- Prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kwon, Hyuk Sung
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Lee, Eun-Hye
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Park, Hyun-Hee
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Jin, Jeong-Hwa
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Choi, Hojin
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Lee, Kyu-Yong
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visa fler...
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Lee, Young Joo
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Lee, Jae-Hong
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de Oliveira, Fel ...
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Kim, Hyun Young
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Kim, Young Seo
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Kim, Bum Joon
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Heo, Sung Hyuk
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Chang, Dae-Il
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Kamali-Moghaddam ...
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Koh, Seong-Ho
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of clini ...
- Av lärosätet
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Uppsala universitet