Sökning: onr:"swepub:oai:DiVA.org:uu-414934" >
Dietary Restriction...
Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes
-
- Mautz, Brian S. (författare)
- Uppsala universitet,Zooekologi,Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.
-
- Lind, Martin I., Dr (författare)
- Uppsala universitet,Zooekologi,Uppsala University, Uppsala, Sweden
-
- Maklakov, Alexei A. (författare)
- Uppsala universitet,Zooekologi,Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, Norfolk, England.
-
(creator_code:org_t)
- 2019-11-25
- 2020
- Engelska.
-
Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences. - : Oxford University Press. - 1079-5006 .- 1758-535X. ; 75:5, s. 843-848
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven lifespan extension can be cost-free, calling into question a central tenant of the evolutionary theory of aging. Nevertheless, boosting parental longevity can reduce offspring fitness. Such intergenerational trade-offs are often ignored but can account for the "missing costs" of longevity. Here, we use the nematode Caenorhabditis remanei to test for effects of DR by fasting on fitness of females and their offspring. Females deprived of food for 6 days indeed had increased fecundity, survival, and stress resistance after re-exposure to food compared with their counterparts with constant food access. However, offspring of DR mothers had reduced early and lifetime fecundity, slower growth rate, and smaller body size at sexual maturity. These findings support the direct trade-off between investment in soma and gametes challenging the hypothesis that increased somatic maintenance and impaired reproduction can be decoupled.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Dietary restriction
- Lifespan extension
- Transgenerational effects
- Temporary fasting
- Reproduction
- Trade-offs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas