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Male sex is strongl...
Male sex is strongly associated with IgE-sensitization to airborne but not food allergens : results up to age 24 years from the BAMSE birth cohort
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- Melen, Erik (författare)
- Karolinska Institutet
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- Bergström, Anna (författare)
- Karolinska Institutet
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- Kull, Inger (författare)
- Karolinska Institutet
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- Malmros, Catarina Almqvist (författare)
- Karolinska Institutet
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- Andersson, Niklas (författare)
- Karolinska Institutet
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- Asarnoj, Anna (författare)
- Karolinska Institutet
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- Borres, Magnus P, 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Georgellis, Antonis (författare)
- Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.;Ctr Occupat & Environm Med, S-11365 Stockholm, Region Stockhol, Sweden.
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- Pershagen, Göran (författare)
- Karolinska Institutet
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- Westman, Marit (författare)
- Karolinska Institutet
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- van Hage, Marianne (författare)
- Karolinska Institutet
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- Ballardini, Natalia (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-05-25
- 2020
- Engelska.
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Ingår i: Clinical and Translational Allergy. - : BioMed Central. - 2045-7022. ; 75, s. 161-162
- Relaterad länk:
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https://doi.org/10.1...
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https://ctajournal.b...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited. Objective To explore IgE-sensitization to common foods and airborne allergens in relation to sex over time in a population-based cohort followed up to young adulthood. Methods The Swedish population-based birth cohort BAMSE includes 4089 subjects who have been followed regularly with questionnaires and clinical investigations. A recent 24-year follow-up included 3069 participants (75%). Sera collected at 4, 8, 16 and 24 years were analyzed for IgE-antibodies to 14 common foods and airborne allergens. Results At 24 years sensitization to foods had decreased compared to previous follow-ups affecting 8.4%, while sensitization to airborne allergens was more common, affecting 42.2%. Male sex was associated with IgE-sensitization to airborne allergens at all ages (overall OR: 1.68, 95% CI 1.46-1.94) while there was no statistically significant association between sex and sensitization to food allergens (overall OR: 1.10, 95% CI 0.93-1.32). Levels of allergen-specific IgE did not differ significantly between males and females for any of the tested foods or airborne allergens at any age, following adjustment for multiple comparisons. Conclusion IgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Allergen
- BAMSE
- Birth cohort
- Immunoglobulin E
- Prevalence
- Sensitization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Melen, Erik
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Bergström, Anna
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Kull, Inger
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Malmros, Catarin ...
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Andersson, Nikla ...
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Asarnoj, Anna
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Borres, Magnus P ...
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Georgellis, Anto ...
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Pershagen, Göran
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Westman, Marit
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van Hage, Marian ...
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Ballardini, Nata ...
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