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Improved Outcome of...
Improved Outcome of Intestinal Failure in Preterm Infants
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- Fredriksson, Fanny, 1985- (författare)
- Uppsala universitet,Barnkirurgisk forskning,Section of Pediatric Surgery, Uppsala University Children's Hospital, Uppsala, Sweden
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- Nyström, Niklas (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Section of Pediatric Gastroenterology, Uppsala University Children's Hospital, Uppsala, Sweden
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- Waldenvik, Kajsa (författare)
- Section of Pediatric Gastroenterology, Uppsala University Children's Hospital, Uppsala, Sweden
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- Ördén, Helene (författare)
- Section of Pediatric Gastroenterology, Uppsala University Children's Hospital, Uppsala, Sweden
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- Lindblom, Maja (författare)
- Section of Pediatric Surgery, Uppsala University Children's Hospital, Uppsala, Sweden
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- Paulsson, Mattias (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi,Hospital Pharmacy, Uppsala University Children's Hospital, Uppsala, Sweden
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- Finkel, Yigael (författare)
- Section of Pediatric Gastroenterology, Uppsala University Children's Hospital, Uppsala, Sweden
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- Engstrand Lilja, Helene, 1963- (författare)
- Uppsala universitet,Barnkirurgisk forskning,Section of Pediatric Surgery, Uppsala University Children's Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Wolters Kluwer, 2020
- 2020
- Engelska.
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Wolters Kluwer. - 0277-2116 .- 1536-4801. ; 71:2, s. 223-231
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The aims were to evaluate the outcome and to identify predictors for survival and enteral autonomy in neonatal intestinal failure (IF).METHODS: A retrospective observational study in a Swedish tertiary centre of children born between 1995 and 2016 with neonatal IF, defined as dependency on parenteral nutrition (PN) ≥60 days, starting with PN before the age of 44 gestational weeks. Data were extracted from medical records and predictors for survival and enteral autonomy were identified by the Cox regression model. Time to death and weaning off PN analysis were performed with Kaplan-Meier curves including log rank test.RESULTS: In total, 105 children were included. Median gestational age was 28 weeks (22-42), 50% were born extremely preterm (<28 gestational weeks). PN started at a median age of two days (0-147) with a median duration of 196 days (60-3091). Necrotising enterocolitis was the dominating cause of IF (61%). Overall survival was 88%, five children died of sepsis and four of intestinal failure-associated liver disease. Survival increased from 75% during 1995-2008 to 96% during 2009-2016 (p = 0.0040). Age-adjusted small bowel length of >50% and birth 2009-2016 were predictors for survival. Enteral autonomy was achieved in 87%, with positive prediction by small bowel length of >25% of expected for gestational age and remaining ileocaecal valve.CONCLUSION: Preterm neonates with IF, at high risk of IF associated morbidity, showed a high overall survival rate. Small-bowel length and being born 2009-2016 were predictors for survival and remaining ICV and small-bowel length were predictors for enteral autonomy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- intestinal failure-associated liver disease
- neonatal surgery
- parenteral nutrition
- taurolidine plus citrate lock
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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